Prenatal diagnosis and outcome of lymphangiomas and its relationship with fetal chromosomal abnormalities

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 29; no. 3; pp. 466 - 472
• Main Authors: Arisoy, Resul, Erdogdu, Emre, Kumru, Pinar, Demirci, Oya, Yuksel, Mehmet Aytac, Pekin, Oya, Tugrul, Semih, Aydin, Hatip
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-02-2016
• Subjects: Adult; Chromosomal abnormalities; Chromosome Aberrations; Female; Fetal Diseases - diagnostic imaging; Fetal Diseases - genetics; genetic counselling; Humans; lymphangioma; Lymphangioma - diagnostic imaging; Lymphangioma - genetics; Male; outcome; Pregnancy; prenatal diagnosis; Retrospective Studies; Ultrasonography, Prenatal; Young Adult; genetic counselling; Chromosomal abnormalities; lymphangioma; prenatal diagnosis; outcome
• ISSN: 1476-7058; 1476-4954
• DOI: 10.3109/14767058.2015.1004536

Objectives: Our aim was to evaluate ultrasound findings and perinatal outcome after prenatal diagnosis of lymphangioma.
Methods: This was a retrospective case series study. We searched the archives of our ultrasound database at our center for cases with the prenatal diagnosis of the lymphangioma in the period between January 2008 and November 2014. We described maternal, fetal and perinatal variables for all cases.
Results: Nine fetuses with lymphangioma were identified. All cases were diagnosed during the second and third trimesters with the average gestational age of 22.6 ± 3.9 weeks. The average diameter of lymphangioma was 55.4 ± 20.1 mm at the time of diagnosis. Five fetuses (55.6%) had lymphangioma on the neck, and four fetuses (44.4%) had lymphangioma on other localizations. Normal fetal karyotype was detected in all cases. There were a total of six live births, one intrauterine death and two medical terminations of pregnancy following the diagnosis of lymphangioma. No abnormal Doppler finding or hydrops were detected in the antenatal follow-up of remaining six cases.
Conclusion: The risk of chromosomal abnormalities is very low in pregnancies with isolated lymphangioma. The outcome of pregnancies with lymphangioma is generally favorable and prognosis depends on their locations and size.