Adult bone marrow-derived mononuclear cells expressing chondroitinase AC transplanted into CNS injury sites promote local brain chondroitin sulphate degradation

Injury to the CNS of vertebrates leads to the formation of a glial scar and production of inhibitory molecules, including chondroitin sulphate proteoglycans. Various studies suggest that the sugar component of the proteoglycan is responsible for the inhibitory role of these compounds in axonal regen...

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Bibliographic Details
Published in:	Journal of neuroscience methods Vol. 171; no. 1; pp. 19 - 29
Main Authors:	Coulson-Thomas, Yvette M., Coulson-Thomas, Vivien J., Filippo, Thais R., Mortara, Renato A., da Silveira, Rafael B., Nader, Helena B., Porcionatto, Marimélia A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-06-2008
Subjects:	Animals Bone Marrow Cells - metabolism Bone Marrow Transplantation - methods Bone marrow-derived cells Brain Injuries - metabolism Brain Injuries - surgery Cell Line Chondroitin Sulfates - metabolism Chondroitin sulphate Chondroitinase AC Chondroitinases and Chondroitin Lyases - genetics Chondroitinases and Chondroitin Lyases - metabolism Cricetinae Cricetulus Female GAP-43 Protein - metabolism Gene Expression Gliosarcoma Glycosaminoglycans - metabolism Green Fluorescent Proteins - biosynthesis Injury Mice Mice, Inbred C57BL Mice, Transgenic Nervous system Transfection - methods Bone marrow-derived cells Nervous system Chondroitinase AC Chondroitin sulphate Injury
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