Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms

Hypoxia serves as a physiologic cue to drive an angiogenic response via HIF-dependent mechanisms. Interestingly, minor elevation of lactate levels in the tissue produces the same effect under aerobic conditions. Aerobic glycolysis contributes to lactate accumulation in the presence of oxygen, especi...

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Bibliographic Details
Published in:	Antioxidants & redox signaling Vol. 9; no. 8; p. 1115
Main Authors:	Hunt, Thomas K, Aslam, Rummana S, Beckert, Stefan, Wagner, Silvia, Ghani, Q Perveen, Hussain, M Zamirul, Roy, Sashwati, Sen, Chandan K
Format:	Journal Article
Language:	English
Published:	United States 01-08-2007
Subjects:	Animals Collagen - chemistry Drug Combinations Female Hydrolysis Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Inflammation L-Lactate Dehydrogenase - metabolism Lactates - metabolism Laminin - chemistry Mice Neovascularization, Physiologic Oxidation-Reduction Oxygen - metabolism Proteoglycans - chemistry Proto-Oncogene Proteins c-kit - biosynthesis Vascular Endothelial Growth Factor A - metabolism
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