Design of polyurea networks containing anticancer and anti‐inflammatory drugs for dual drug delivery purposes

• Published in: Journal of applied polymer science Vol. 139; no. 16
• Main Authors: Resende, Mariane A., Pedroza, Gabriele A., Macêdo, Lucia H. G. M. C., Oliveira, Ricardo, Amela‐Cortes, Maria, Molard, Yann, Molina, Eduardo F.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 20-04-2022; Wiley Subscription Services, Inc; Wiley
• Subjects: Amines; Cancer; Chain mobility; Chemical compounds; Chemical Sciences; Contact lenses; Differential scanning calorimetry; drug delivery systems; Drugs; elastomers; Fourier transforms; glass transition; Hexamethylene diisocyanate; Infrared spectroscopy; Materials science; Naproxen; Pharmacology; polyetheramine; Polyethers; Polymers; Polyureas; Segments; Small angle X ray scattering; Sol-gel processes; Solvation; spectroscopy; Trimers; Xerogels; drug delivery systems; polyetheramine; glass transition; elastomers; spectroscopy
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.51970

Naproxen (Nap), a non‐steroidal anti‐inflammatory drug, and 5‐fluorouracil (5FU), an anticancer drug, were easily incorporated into a polyurea xerogel. Polyureas (PUr) were synthesized by one pot reaction via sol–gel chemistry. Soft segments were based on polyetheramine‐PEO and hard segments were based on a hexamethylene diisocyanate trimer (HDI). The final materials were characterized by Fourier transform infrared (FTIR) spectroscopy, small‐angle X‐ray scattering (SAXS), and differential scanning calorimetry (DSC). Polyurea can assume many forms revealing its versatility in terms of produced shapes. In good agreement with FTIR, SAXS studies showed a microphase separated structure arising from inter‐hard‐domain spacings, which remains unchanged after incorporation of the drugs. DSC analysis demonstrated that the PEO chain mobility was poorly affected after the drugs incorporation due to the solvation of the drugs through the network. The water uptake and the amount of drug released agree well, playing an important role for controlled Nap and 5FU release. This work opens positive perspectives for ocular drug delivery and wound management, due to the easy processability of the xerogel, which has high feasibility to be moldable as pharmaceutical devices for contact lenses and transdermal patches purposes containing distinct therapeutic agents.
The successful dual‐drug release highlights the polyurea xerogel as a versatile carrier to combine anti‐inflamatory and anticancer drugs into a single polymer matrix, opening new oportunities to develop functional materials containing different species for optical, health and environmental applications.