Recent advances in local drug delivery to the inner ear

• Published in: International journal of pharmaceutics Vol. 494; no. 1; pp. 83 - 101
• Main Authors: El Kechai, Naila, Agnely, Florence, Mamelle, Elisabeth, Nguyen, Yann, Ferrary, Evelyne, Bochot, Amélie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-10-2015
• Subjects: Cochlea; Cochlea - drug effects; Drug Delivery Systems - methods; Humans; Hydrogels; Intracochlear administration; Intratympanic administration; Labyrinth Diseases - drug therapy; Medical drug delivery devices; Nanoparticulate systems; Perilymph - metabolism; Pharmaceutical Preparations - administration & dosage; LNC; Hydrogels; Nanoparticulate systems; RW; CMAP; JNK; TTI; Intratympanic administration; BSA; FITC; HBPL; AIED; BPLB; NIHL; SPION; BDNF; HGF; GMO; IGF; CMV; PEG-PCL; PHEA; PLGA; Medical drug delivery devices; Cochlea; HA; SNHL; PK; Intracochlear administration
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2015.08.015

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Inner ear diseases are not adequately treated by systemic drug administration mainly because of the blood–perilymph barrier that reduces exchanges between plasma and inner ear fluids. Local drug delivery methods including intratympanic and intracochlear administrations are currently developed to treat inner ear disorders more efficiently. Intratympanic administration is minimally invasive but relies on diffusion through middle ear barriers for drug entry into the cochlea, whereas intracochlear administration offers direct access to the colchlea but is rather invasive. A wide range of drug delivery systems or devices were evaluated in research and clinic over the last decade for inner ear applications. In this review, different strategies including medical devices, hydrogels and nanoparticulate systems for intratympanic administration, and cochlear implant coating or advanced medical devices for intracoclear administration were explored with special attention to in vivo studies. This review highlights the promising systems for future clinical applications as well as the current hurdles that remain to be overcome for efficient inner ear therapy.