Scedosporium aurantiacum: First isolation in Argentina from a previously healthy patient after traumatic inoculation

•First case of S. aurantiacum in our country from a pediatric patient.•Improved methods are necessary for the identification of species of this genus.•Voriconazole proved to be most effective antifungal in the treatment and led to a favorable clinical outcome. Scedosporium/Lomentospora species are w...

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Published in:Revista argentina de microbiología Vol. 54; no. 4; pp. 318 - 321
Main Authors: Carnovale, Susana, Epelbaum, Carolina, Abrantes, Ruben, Córdoba, Susana, Cabrera, Carla, Caracciolo, Beatriz
Format: Journal Article
Language:English
Published: Argentina Elsevier España, S.L.U 01-10-2022
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Abstract •First case of S. aurantiacum in our country from a pediatric patient.•Improved methods are necessary for the identification of species of this genus.•Voriconazole proved to be most effective antifungal in the treatment and led to a favorable clinical outcome. Scedosporium/Lomentospora species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised patients and occasionally in immunocompetent patients that are difficult to treat due to high levels of antifungal resistance. The distribution of Scedosporium/Lomentospora species shows regional differences. Scedosporium boydii and Scedosporium apiospermum are the most frequently isolated species in our region, whereas Scedosporium aurantiacum is more common in other regions. We describe the first isolation in Argentina of S. aurantiacum in a vitreous humor infection from a previously healthy patient after traumatic injury in her left eye. Due to the suspicion of fungal endophthalmitis, a mycological study of the vitreous humor was performed. The culture allowed the isolation of S. aurantiacum. The patient was treated with voriconazole with favorable clinic evolution. Las especies de Scedosporium/Lamentospora se encuentran ampliamente distribuidas en la naturaleza. En general son saprófitas, pero pueden causar infecciones oportunistas de difícil tratamiento debido a sus altos niveles de resistencia a los antifúngicos en individuos inmunocomprometidos y, ocasionalmente, en personas inmunocompetentes. La distribución de las especies de Scedosporium/Lamentospora muestra diferencias regionales. Scedosporium boydii y S. apiospermum son las especies más frecuentemente aisladas en nuestra región, mientras que en otras S. aurantiacum es más común. Presentamos el primer aislamiento en Argentina de S. aurantiacum de una infección de humor vítreo de un paciente previamente sano que sufrió una lesión traumática. El paciente fue tratado con voriconazol y tuvo una evolución clínica favorable.
AbstractList Scedosporium/Lomentospora species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised patients and occasionally in immunocompetent patients that are difficult to treat due to high levels of antifungal resistance. The distribution of Scedosporium/Lomentospora species shows regional differences. Scedosporium boydii and Scedosporium apiospermum are the most frequently isolated species in our region, whereas Scedosporium aurantiacum is more common in other regions. We describe the first isolation in Argentina of S. aurantiacum in a vitreous humor infection from a previously healthy patient after traumatic injury in her left eye. Due to the suspicion of fungal endophthalmitis, a mycological study of the vitreous humor was performed. The culture allowed the isolation of S. aurantiacum. The patient was treated with voriconazole with favorable clinic evolution.
•First case of S. aurantiacum in our country from a pediatric patient.•Improved methods are necessary for the identification of species of this genus.•Voriconazole proved to be most effective antifungal in the treatment and led to a favorable clinical outcome. Scedosporium/Lomentospora species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised patients and occasionally in immunocompetent patients that are difficult to treat due to high levels of antifungal resistance. The distribution of Scedosporium/Lomentospora species shows regional differences. Scedosporium boydii and Scedosporium apiospermum are the most frequently isolated species in our region, whereas Scedosporium aurantiacum is more common in other regions. We describe the first isolation in Argentina of S. aurantiacum in a vitreous humor infection from a previously healthy patient after traumatic injury in her left eye. Due to the suspicion of fungal endophthalmitis, a mycological study of the vitreous humor was performed. The culture allowed the isolation of S. aurantiacum. The patient was treated with voriconazole with favorable clinic evolution. Las especies de Scedosporium/Lamentospora se encuentran ampliamente distribuidas en la naturaleza. En general son saprófitas, pero pueden causar infecciones oportunistas de difícil tratamiento debido a sus altos niveles de resistencia a los antifúngicos en individuos inmunocomprometidos y, ocasionalmente, en personas inmunocompetentes. La distribución de las especies de Scedosporium/Lamentospora muestra diferencias regionales. Scedosporium boydii y S. apiospermum son las especies más frecuentemente aisladas en nuestra región, mientras que en otras S. aurantiacum es más común. Presentamos el primer aislamiento en Argentina de S. aurantiacum de una infección de humor vítreo de un paciente previamente sano que sufrió una lesión traumática. El paciente fue tratado con voriconazol y tuvo una evolución clínica favorable.
Author Abrantes, Ruben
Córdoba, Susana
Caracciolo, Beatriz
Carnovale, Susana
Epelbaum, Carolina
Cabrera, Carla
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Keywords Endophthalmitis
Scedosporium aurantiacum
Argentina
Endoftalmitis
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Snippet •First case of S. aurantiacum in our country from a pediatric patient.•Improved methods are necessary for the identification of species of this...
Scedosporium/Lomentospora species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised...
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StartPage 318
SubjectTerms Antifungal Agents - therapeutic use
Argentina
Ascomycota
Endoftalmitis
Endophthalmitis
Humans
Scedosporium
Scedosporium aurantiacum
Voriconazole - therapeutic use
Title Scedosporium aurantiacum: First isolation in Argentina from a previously healthy patient after traumatic inoculation
URI https://dx.doi.org/10.1016/j.ram.2022.02.002
https://www.ncbi.nlm.nih.gov/pubmed/35643584
https://search.proquest.com/docview/2672318870
Volume 54
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