Association between Carotid and Coronary Artery Disease in Patients with Aortic Valve Stenosis: An Angiographic Study
Background Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease. Methods The study includes 317 consecutive patients with aortic stenosis, who underwent carotid and...
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| Published in: | Angiology Vol. 60; no. 5; pp. 596 - 600 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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SAGE Publications
01-10-2009
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| Abstract | Background
Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease.
Methods
The study includes 317 consecutive patients with aortic stenosis, who underwent carotid and coronary angiography during the same catheterization before aortic valve replacement.
Results
At univariate analysis, the prevalence of coronary artery disease was associated with (1) presence of carotid artery disease (P < .001); (2) angina pectoris as presentation symptom (P < .001); (3) age more than 65 years (P < .05); and (4) hypertension (P < .05). At multivariate analysis, only carotid artery disease, angina, and age emerged as independent predictors of coronary artery disease. The combination of 2 variables (carotid artery disease, angina) allowed the identification of 4 groups, with decreasing prevalence of coronary artery disease: (1) angina+/carotid artery disease+: 85%; (2) angina—/ carotid artery disease+: 50%; (3) angina+/carotid artery disease—: 41%; (4) angina—/carotid artery disease—: 21% (P < .001).
Conclusion
In patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease. |
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| AbstractList | Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease.
The study includes 317 consecutive patients with aortic stenosis, who underwent carotid and coronary angiography during the same catheterization before aortic valve replacement.
At univariate analysis, the prevalence of coronary artery disease was associated with (1) presence of carotid artery disease (P < .001); (2) angina pectoris as presentation symptom (P < .001); (3) age more than 65 years (P < .05); and (4) hypertension (P < .05). At multivariate analysis, only carotid artery disease, angina, and age emerged as independent predictors of coronary artery disease. The combination of 2 variables (carotid artery disease, angina) allowed the identification of 4 groups, with decreasing prevalence of coronary artery disease: (1) angina+/carotid artery disease+: 85%; (2) angina-/ carotid artery disease+: 50%; (3) angina+/carotid artery disease-: 41%; (4) angina-/carotid artery disease-: 21% (P < .001).
In patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease. BACKGROUNDPatients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease.METHODSThe study includes 317 consecutive patients with aortic stenosis, who underwent carotid and coronary angiography during the same catheterization before aortic valve replacement.RESULTSAt univariate analysis, the prevalence of coronary artery disease was associated with (1) presence of carotid artery disease (P < .001); (2) angina pectoris as presentation symptom (P < .001); (3) age more than 65 years (P < .05); and (4) hypertension (P < .05). At multivariate analysis, only carotid artery disease, angina, and age emerged as independent predictors of coronary artery disease. The combination of 2 variables (carotid artery disease, angina) allowed the identification of 4 groups, with decreasing prevalence of coronary artery disease: (1) angina+/carotid artery disease+: 85%; (2) angina-/ carotid artery disease+: 50%; (3) angina+/carotid artery disease-: 41%; (4) angina-/carotid artery disease-: 21% (P < .001).CONCLUSIONIn patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease. Background Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery disease and carotid artery disease. Methods The study includes 317 consecutive patients with aortic stenosis, who underwent carotid and coronary angiography during the same catheterization before aortic valve replacement. Results At univariate analysis, the prevalence of coronary artery disease was associated with (1) presence of carotid artery disease (P < .001); (2) angina pectoris as presentation symptom (P < .001); (3) age more than 65 years (P < .05); and (4) hypertension (P < .05). At multivariate analysis, only carotid artery disease, angina, and age emerged as independent predictors of coronary artery disease. The combination of 2 variables (carotid artery disease, angina) allowed the identification of 4 groups, with decreasing prevalence of coronary artery disease: (1) angina+/carotid artery disease+: 85%; (2) angina—/ carotid artery disease+: 50%; (3) angina+/carotid artery disease—: 41%; (4) angina—/carotid artery disease—: 21% (P < .001). Conclusion In patients with symptomatic aortic stenosis, the presence of significant carotid artery disease is a strong marker of significant coronary artery disease. |
| Author | Burelli, Claudio Capanna, Michele Macor, Franco Grandis, Umberto Nicolosi, Gian Luigi Cassin, Matteo Antonini-Canterin, Francesco Leiballi, Elisa |
| Author_xml | – sequence: 1 givenname: Francesco surname: Antonini-Canterin fullname: Antonini-Canterin, Francesco – sequence: 2 givenname: Elisa surname: Leiballi fullname: Leiballi, Elisa – sequence: 3 givenname: Michele surname: Capanna fullname: Capanna, Michele – sequence: 4 givenname: Claudio surname: Burelli fullname: Burelli, Claudio – sequence: 5 givenname: Matteo surname: Cassin fullname: Cassin, Matteo – sequence: 6 givenname: Franco surname: Macor fullname: Macor, Franco – sequence: 7 givenname: Umberto surname: Grandis fullname: Grandis, Umberto – sequence: 8 givenname: Gian Luigi surname: Nicolosi fullname: Nicolosi, Gian Luigi |
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| CitedBy_id | crossref_primary_10_1002_ccd_27346 crossref_primary_10_1016_j_amjcard_2023_04_031 crossref_primary_10_1002_ccd_25585 crossref_primary_10_1016_j_jacc_2010_12_005 crossref_primary_10_7793_jcoron_19_002 crossref_primary_10_1007_s00392_015_0824_5 crossref_primary_10_5812_iranjradiol_14260 crossref_primary_10_1093_eurheartj_ehq406 crossref_primary_10_1007_s00392_012_0486_5 crossref_primary_10_4244_EIJV7I5A90 crossref_primary_10_1016_j_atherosclerosis_2012_06_011 |
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| Keywords | coronary artery disease aortic valve stenosis carotid artery disease Human Aortic stenosis Angiography Cardiac valvular disease Blood vessel Carotid Cardiovascular disease Circulatory system Coronary heart disease Aortic valve Artery |
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Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary... Patients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary artery... BACKGROUNDPatients with aortic stenosis have a high prevalence of coronary artery disease, but there is little information about the association of coronary... |
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| SubjectTerms | Age Factors Aged Angina Pectoris - etiology Aortic Valve Stenosis - complications Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - epidemiology Aortic Valve Stenosis - surgery Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Artery Diseases - complications Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Coronary Angiography Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Diseases of the aorta Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Heart Valve Prosthesis Implantation Humans Hypertension - complications Male Medical sciences Middle Aged Multivariate Analysis Predictive Value of Tests Prevalence Prospective Studies Risk Assessment Risk Factors |
| Title | Association between Carotid and Coronary Artery Disease in Patients with Aortic Valve Stenosis: An Angiographic Study |
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