Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function

The resident stem cells of skeletal muscle are satellite cells, which are regulated by both canonical and non-canonical Wnt pathways. Canonical Wnt signalling promotes differentiation, and is controlled at many levels, including via Axin1 and Axin2-mediated β-catenin degradation. Axin1 and Axin2 are...

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Bibliographic Details
Published in:	Cellular signalling Vol. 27; no. 8; pp. 1652 - 1665
Main Authors:	Figeac, Nicolas, Zammit, Peter S.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01-08-2015
Subjects:	Animals Axin Protein - deficiency Axin Protein - genetics Axin Protein - metabolism Axin1 Axin2 beta Catenin - genetics beta Catenin - metabolism Cell Differentiation Cell Proliferation Cell Shape Cells, Cultured Gene Expression Regulation, Developmental Mice, Inbred C57BL Mice, Knockout Muscle Development Muscle Fibers, Skeletal - metabolism RNA Interference Satellite cell Satellite Cells, Skeletal Muscle - metabolism Skeletal muscle Stem cell Time Factors Transcription, Genetic Transfection Wnt Signaling Pathway β-catenin β-catenin Axin1 Axin2 Satellite cell Stem cell Skeletal muscle
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