A Comparative Evaluation of TRPS1 and GATA3 in adenoid cystic, secretory, and acinic cell carcinomas of the breast and salivary gland

• Published in: Human pathology Vol. 145; pp. 42 - 47
• Main Authors: Salem, Alireza, Wu, Yun, Albarracin, Constance T., Middleton, Lavinia P., Kalhor, Neda, Peng, Yan, Huang, Xiao, Aung, Phyu P., Chen, Hui, Sahin, Aysegul A., Ding, Qingqing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-03-2024
• Subjects: Adenoids - metabolism; Adenoids - pathology; Biomarkers, Tumor - metabolism; Breast; Breast Neoplasms - pathology; Carcinoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic - pathology; Female; Fingers - abnormalities; GATA3; GATA3 Transcription Factor; Hair Diseases; Head and neck; Humans; Langer-Giedion Syndrome; Nose - abnormalities; Repressor Proteins; Salivary Gland Neoplasms - pathology; Salivary Glands - metabolism; Salivary Glands - pathology; salivary gland–type carcinomas; Triple Negative Breast Neoplasms - pathology; Triple-negative breast carcinoma; TRPS1; Upper respiratory; salivary gland–type carcinomas; Triple-negative breast carcinoma; TRPS1; Upper respiratory; Breast; Head and neck; GATA3
• ISSN: 0046-8177; 1532-8392; 1532-8392
• DOI: 10.1016/j.humpath.2024.01.004

GATA3 is the most used marker to determine tumors’ breast origin, but its diagnostic value in triple-negative breast cancer (TNBC) is limited. The newly identified TRPS1 is highly sensitive and specific for breast carcinoma, especially TNBC. Here, we compared the utility of TRPS1 and GATA3 expression in a subset of salivary gland–type breast tumors (including adenoid cystic, acinic cell, and secretory carcinomas [AdCC, ACC, and SC, respectively]), and we compared TRPS1 and GATA3 expression of such tumors with head and neck (H&N) and AdCC of upper respiratory tumors. TRPS1 was strongly expressed in basaloid TNBC and AdCCs with solid components, including 100 % of mixed and solid breast AdCCs. However, TRPS1 was positive in only 50 % cribriform AdCCs. Expression patterns of TRPS1 in H&N and upper respiratory AdCC were similar. TRPS1 was positive in 30 % of H&N cribriform AdCCs but was strongly expressed in mixed AdCC (67 %) and solid AdCC (100 %). In the upper respiratory AdCCs, TRPS1 was positive in 58.4 % of cribriform AdCCs and positive in 100 % of AdCCs with solid components. On the contrary, GATA3 was negative in predominant AdCCs of the breast, H&N, and upper respiratory tract. These data show that GATA3 and TRPS1 expression varies AdCCs. In addition, TRPS1 and GATA3 expression patterns were similar SC and ACC of breast and H&N. Both markers were positive in SC and negative in ACC. Therefore, TRPS1 and GATA3 cannot be used to differentiate salivary gland–type carcinomas of breast origin from those of upper respiratory or H&N origin.