A Systematic Scoping Review of Comparative Effectiveness Studies in Kidney Stone Disease

• Published in: Urology (Ridgewood, N.J.) Vol. 183; pp. 3 - 10
• Main Authors: Dangle, Pankaj, Tasian, Gregory E., Chu, David I., Shannon, Rachel, Spiardi, Ryan, Xiang, Alice H., Jadcherla, Aditya, Arenas, Juliana, Ellison, Jonathan S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-01-2024
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2023.08.042

To review the status of comparative effectiveness studies for kidney stone disease with focus on study outcome, type, population, time trends, and patient-centered approaches.
A systematic scoping review was performed for articles published between January 1, 2005, and March 30, 2021, using keywords relevant to kidney stone disease. Studies published in English that compared two or more alternative methods for prevention, diagnosis, treatment, monitoring, or care delivery were included. Two reviewers independently reviewed abstracts and an arbitrator resolved discrepancies. Nine reviewers abstracted information from full-length studies. Descriptive statistics were summarized, and linear regression was performed to evaluate temporal trends of study characteristics.
We reviewed 1773 abstracts and 707 full-length manuscripts focused on surgical intervention (440); medical expulsive therapy (MET) (152); analgesic control (80); and homeopathic, diagnostics, and/or prophylaxis (84). Randomized controlled trials were common across all outcome categories, including surgery (41.6%), MET (60.2%), analgesic control (81.3%), homeopathic (41.2%), diagnostic (47.6%), and prophylaxis (49.1%). Patient-reported outcomes were utilized in 71.7% and 95% of MET and analgesic control studies, respectively, but in the minority of all other study themes. Over time, meta-analyses and multicenter studies increased [P < .001].
Surgical and MET themes dominate published comparative literature in kidney stone disease. There is substantial variation in use of patient-reported outcomes across surgical themes. Multicentered studies and those generating higher level evidence have increased over time but opportunities exist to improve collaborative, high-quality, and patient-centered research in kidney stone disease.