Topical iontophoresis of buflomedil hydrochloride increases drug bioavailability in the mucosa: A targeted approach to treat oral submucous fibrosis

[Display omitted] The aim was to investigate the effect of constant current iontophoresis on the delivery and biodistribution of buflomedil hydrochloride (BUF) in the buccal mucosa. Quantification was by UHPLC-MS/MS; in addition to total delivery, the amounts present in the epithelia and the lamina...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 569; p. 118610
Main Authors:	Tyagi, Vasundhara, del Río-Sancho, Sergio, Lapteva, Maria, Kalia, Yogeshvar N.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 05-10-2019
Subjects:	Administration, Cutaneous Animals Biological Availability Buccal delivery Buflomedil Esophageal Mucosa - metabolism Fibrosis Hydrogels - administration & dosage Iontophoresis Oral Submucous Fibrosis - drug therapy Pyrrolidines - administration & dosage Swine Topical delivery Vasodilator Agents - administration & dosage Iontophoresis Buflomedil Topical delivery Buccal delivery Fibrosis
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