Left atrial stiffness and strain are novel indices of left ventricular diastolic function in children: validation followed by application in multisystem inflammatory syndrome in children due to COVID-19
Abstract Aims We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction in myocardial injury due to multisystem inflammatory syndrome in children (MIS-C)...
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| Published in: | European heart journal cardiovascular imaging Vol. 24; no. 9; pp. 1241 - 1251 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Oxford University Press
23-08-2023
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| Abstract | Abstract
Aims
We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction in myocardial injury due to multisystem inflammatory syndrome in children (MIS-C).
Methods and results
We validated LA stiffness in 76 patients (median age 10.5 years), 33 had normal PCWP (<12 mmHg) and 43 had elevated PCWP (≥12 mmHg). LA stiffness was applied to 42 MIS-C patients [28 with myocardial injury (+) and 14 without myocardial injury (−)], defined by serum biomarkers. The validation group consisted of a group with and without cardiomyopathies, whose PCWP values ranged from normal to severely elevated. Peak LA strain was measured by speckle-tracking and E/e′ from apical four chamber views. Noninvasive LA stiffness was calculated as: LAStiffness=E/e′LAPeakStrain (%−1). Patients with elevated PCWP showed significantly elevated LA stiffness [median 0.71%−1 vs. 0.17%−1, P < 0.001]. Elevated PCWP group showed significantly decreased LA strain (median: 15.0% vs. 38.2%, P < 0.001). Receiver operator characteristic (ROC) curve for LA stiffness yielded an area under the curve (AUC) of 0.88 and cutoff value of 0.27%−1. In MIS-C group, ROC curve yielded an AUC of 0.79 and cutoff value of 0.29%−1 for identifying myocardial injury.
Conclusion
In children with elevated PCWP, LA stiffness was significantly increased. When applied to children with MIS-C, LA stiffness classified myocardial injury accurately. LA stiffness and strain may serve as noninvasive markers of diastolic function in the pediatric population.
Graphical Abstract
Graphical Abstract |
|---|---|
| AbstractList | Abstract
Aims
We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction in myocardial injury due to multisystem inflammatory syndrome in children (MIS-C).
Methods and results
We validated LA stiffness in 76 patients (median age 10.5 years), 33 had normal PCWP (<12 mmHg) and 43 had elevated PCWP (≥12 mmHg). LA stiffness was applied to 42 MIS-C patients [28 with myocardial injury (+) and 14 without myocardial injury (−)], defined by serum biomarkers. The validation group consisted of a group with and without cardiomyopathies, whose PCWP values ranged from normal to severely elevated. Peak LA strain was measured by speckle-tracking and E/e′ from apical four chamber views. Noninvasive LA stiffness was calculated as: LAStiffness=E/e′LAPeakStrain (%−1). Patients with elevated PCWP showed significantly elevated LA stiffness [median 0.71%−1 vs. 0.17%−1, P < 0.001]. Elevated PCWP group showed significantly decreased LA strain (median: 15.0% vs. 38.2%, P < 0.001). Receiver operator characteristic (ROC) curve for LA stiffness yielded an area under the curve (AUC) of 0.88 and cutoff value of 0.27%−1. In MIS-C group, ROC curve yielded an AUC of 0.79 and cutoff value of 0.29%−1 for identifying myocardial injury.
Conclusion
In children with elevated PCWP, LA stiffness was significantly increased. When applied to children with MIS-C, LA stiffness classified myocardial injury accurately. LA stiffness and strain may serve as noninvasive markers of diastolic function in the pediatric population.
Graphical Abstract
Graphical Abstract AIMSWe hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction in myocardial injury due to multisystem inflammatory syndrome in children (MIS-C). METHODS AND RESULTSWe validated LA stiffness in 76 patients (median age 10.5 years), 33 had normal PCWP (<12 mmHg) and 43 had elevated PCWP (≥12 mmHg). LA stiffness was applied to 42 MIS-C patients [28 with myocardial injury (+) and 14 without myocardial injury (-)], defined by serum biomarkers. The validation group consisted of a group with and without cardiomyopathies, whose PCWP values ranged from normal to severely elevated. Peak LA strain was measured by speckle-tracking and E/e' from apical four chamber views. Noninvasive LA stiffness was calculated as: LAStiffness=E/e'LAPeakStrain (%-1). Patients with elevated PCWP showed significantly elevated LA stiffness [median 0.71%-1 vs. 0.17%-1, P < 0.001]. Elevated PCWP group showed significantly decreased LA strain (median: 15.0% vs. 38.2%, P < 0.001). Receiver operator characteristic (ROC) curve for LA stiffness yielded an area under the curve (AUC) of 0.88 and cutoff value of 0.27%-1. In MIS-C group, ROC curve yielded an AUC of 0.79 and cutoff value of 0.29%-1 for identifying myocardial injury. CONCLUSIONIn children with elevated PCWP, LA stiffness was significantly increased. When applied to children with MIS-C, LA stiffness classified myocardial injury accurately. LA stiffness and strain may serve as noninvasive markers of diastolic function in the pediatric population. We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction in myocardial injury due to multisystem inflammatory syndrome in children (MIS-C). We validated LA stiffness in 76 patients (median age 10.5 years), 33 had normal PCWP (<12 mmHg) and 43 had elevated PCWP (≥12 mmHg). LA stiffness was applied to 42 MIS-C patients [28 with myocardial injury (+) and 14 without myocardial injury (-)], defined by serum biomarkers. The validation group consisted of a group with and without cardiomyopathies, whose PCWP values ranged from normal to severely elevated. Peak LA strain was measured by speckle-tracking and E/e' from apical four chamber views. Noninvasive LA stiffness was calculated as: LAStiffness=E/e'LAPeakStrain (%-1). Patients with elevated PCWP showed significantly elevated LA stiffness [median 0.71%-1 vs. 0.17%-1, P < 0.001]. Elevated PCWP group showed significantly decreased LA strain (median: 15.0% vs. 38.2%, P < 0.001). Receiver operator characteristic (ROC) curve for LA stiffness yielded an area under the curve (AUC) of 0.88 and cutoff value of 0.27%-1. In MIS-C group, ROC curve yielded an AUC of 0.79 and cutoff value of 0.29%-1 for identifying myocardial injury. In children with elevated PCWP, LA stiffness was significantly increased. When applied to children with MIS-C, LA stiffness classified myocardial injury accurately. LA stiffness and strain may serve as noninvasive markers of diastolic function in the pediatric population. |
| Author | Zuckerberg, Jeremy C Banerjee, Anirban Matsubara, Daisuke Patel, Chandni Hogarty, Alexa N Quartermain, Michael D Calderon-Anyosa, Renzo Kauffman, Hunter L Falkensammer, Christine B Chang, Joyce C Mercer-Rosa, Laura M Wang, Yan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37159912$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jcmg.2017.07.029 10.1016/S0140-6736(20)31094-1 10.1016/j.jcmg.2016.08.014 10.1016/j.jacc.2020.08.056 10.1007/s00246-014-1018-z 10.4250/jcu.2011.19.4.169 10.1016/j.echo.2011.10.010 10.1016/j.jacc.2018.08.1038 10.1007/s10554-018-1429-7 10.1161/01.CIR.102.15.1788 10.32614/RJ-2016-042 10.1161/CIRCIMAGING.108.813071 10.1093/eurheartj/ehm037 10.1161/CIRCIMAGING.112.000175 10.1016/j.echo.2009.04.026 10.1056/NEJMoa2021756 10.1016/S0140-6736(20)31103-X 10.1111/echo.13094 10.1016/j.echo.2016.01.011 10.1016/S0002-8703(96)90183-0 10.1161/CIRCIMAGING.117.006738 10.1016/j.jacc.2020.06.007 |
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| Copyright_xml | – notice: The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023 – notice: The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
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| References | Ommen (2023082310044735600_jead087-B4) 2000; 102 Verdoni (2023082310044735600_jead087-B10) 2020; 395 Dragulescu (2023082310044735600_jead087-B5) 2013; 6 Paulus (2023082310044735600_jead087-B13) 2007; 28 Wakami (2023082310044735600_jead087-B8) 2009; 22 Nagueh (2023082310044735600_jead087-B1) 2016; 4 Sasaki (2023082310044735600_jead087-B6) 2015; 36 Dufort (2023082310044735600_jead087-B16) 2020; 383 Cameli (2023082310044735600_jead087-B20) 2016; 33 Morris (2023082310044735600_jead087-B22) 2018; 11 Matsubara (2023082310044735600_jead087-B12) 2020; 76 Kurt (2023082310044735600_jead087-B7) 2009; 2 Goksuluk (2023082310044735600_jead087-B19) 2016; 8 Ghelani (2023082310044735600_jead087-B25) 2018; 11 Park (2023082310044735600_jead087-B2) 2011; 19 World Health Organization Scientific Brief (2023082310044735600_jead087-B15) CDC Health Alert Network (2023082310044735600_jead087-B14) Khoo (2023082310044735600_jead087-B18) 2012; 25 Hope (2023082310044735600_jead087-B9) 2019; 35 Rodriguez (2023082310044735600_jead087-B3) 1996; 131 Riphagen (2023082310044735600_jead087-B11) 2020; 395 Lala (2023082310044735600_jead087-B17) 2020; 76 Thygesen (2023082310044735600_jead087-B24) 2018; 72 Kim (2023082310044735600_jead087-B23) 2022; 16 Singh (2023082310044735600_jead087-B21) 2017; 10 |
| References_xml | – volume: 11 start-page: 1405 year: 2018 ident: 2023082310044735600_jead087-B22 article-title: Potential usefulness and clinical relevance of adding left atrial strain to left atrial volume Index in the detection of left ventricular diastolic dysfunction publication-title: JACC Cardiovasc Imaging doi: 10.1016/j.jcmg.2017.07.029 contributor: fullname: Morris – volume: 395 start-page: 1607 year: 2020 ident: 2023082310044735600_jead087-B11 article-title: Hyperinflammatory shock in children during COVID-19 pandemic publication-title: Lancet doi: 10.1016/S0140-6736(20)31094-1 contributor: fullname: Riphagen – volume: 10 start-page: 735 year: 2017 ident: 2023082310044735600_jead087-B21 article-title: LA Strain for categorization of LV diastolic dysfunction publication-title: JACC Cardiovasc Imaging doi: 10.1016/j.jcmg.2016.08.014 contributor: fullname: Singh – ident: 2023082310044735600_jead087-B14 contributor: fullname: CDC Health Alert Network – volume: 76 start-page: S0735-1097(20)36488-3 year: 2020 ident: 2023082310044735600_jead087-B12 article-title: Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2020.08.056 contributor: fullname: Matsubara – volume: 36 start-page: 386 year: 2015 ident: 2023082310044735600_jead087-B6 article-title: Applicability of published guidelines for assessment of left ventricular diastolic function in adults to children with restrictive cardiomyopathy: an observational study publication-title: Pediatr Cardiol doi: 10.1007/s00246-014-1018-z contributor: fullname: Sasaki – volume: 19 start-page: 169 year: 2011 ident: 2023082310044735600_jead087-B2 article-title: Use and limitations of E/e′ to assess left ventricular filling pressure by echocardiography publication-title: J Cardiovasc Ultrasound doi: 10.4250/jcu.2011.19.4.169 contributor: fullname: Park – volume: 25 start-page: 294 year: 2012 ident: 2023082310044735600_jead087-B18 article-title: Altered left ventricular tissue velocities, deformation and twist in children and young adults with acute myocarditis and normal ejection fraction publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2011.10.010 contributor: fullname: Khoo – volume: 72 start-page: 2231 year: 2018 ident: 2023082310044735600_jead087-B24 article-title: Fourth universal definition of myocardial infarction (2018) publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.08.1038 contributor: fullname: Thygesen – volume: 35 start-page: 57 year: 2019 ident: 2023082310044735600_jead087-B9 article-title: Left atrial mechanics in children: insights from new applications of strain imaging publication-title: Int J Cardiovasc Imaging doi: 10.1007/s10554-018-1429-7 contributor: fullname: Hope – volume: 102 start-page: 1788 year: 2000 ident: 2023082310044735600_jead087-B4 article-title: Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures a comparative simultaneous Doppler-catheterization study publication-title: Circulation doi: 10.1161/01.CIR.102.15.1788 contributor: fullname: Ommen – volume: 8 start-page: 213 year: 2016 ident: 2023082310044735600_jead087-B19 article-title: EasyROC: an interactive web-tool for ROC curve analysis using R language environment publication-title: R J doi: 10.32614/RJ-2016-042 contributor: fullname: Goksuluk – volume: 2 start-page: 10 year: 2009 ident: 2023082310044735600_jead087-B7 article-title: Left atrial function in diastolic heart failure publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.108.813071 contributor: fullname: Kurt – volume: 28 start-page: 2539 year: 2007 ident: 2023082310044735600_jead087-B13 article-title: How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the heart failure and echocardiography associations of the European Society of Cardiology publication-title: Eur Heart J doi: 10.1093/eurheartj/ehm037 contributor: fullname: Paulus – volume: 6 start-page: 254 year: 2013 ident: 2023082310044735600_jead087-B5 article-title: Interpretation of left ventricular diastolic dysfunction in children with cardiomyopathy by echocardiography: problems and limitations publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.112.000175 contributor: fullname: Dragulescu – volume: 16 start-page: S1936-878X(22)00662-3 year: 2022 ident: 2023082310044735600_jead087-B23 article-title: Prognostic implications of left atrial stiffness Index in heart failure patients with preserved ejection fraction publication-title: JACC Cardiovas Imaging contributor: fullname: Kim – volume: 22 start-page: 847 year: 2009 ident: 2023082310044735600_jead087-B8 article-title: Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2009.04.026 contributor: fullname: Wakami – volume: 383 start-page: 347 year: 2020 ident: 2023082310044735600_jead087-B16 article-title: Multisystem inflammatory syndrome in children in New York state publication-title: N Engl J Med doi: 10.1056/NEJMoa2021756 contributor: fullname: Dufort – volume: 395 start-page: 1771 year: 2020 ident: 2023082310044735600_jead087-B10 article-title: An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study publication-title: Lancet doi: 10.1016/S0140-6736(20)31103-X contributor: fullname: Verdoni – volume: 33 start-page: 398 year: 2016 ident: 2023082310044735600_jead087-B20 article-title: Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular End-diastolic pressure in patients stratified for different values of ejection fraction publication-title: Echocardiography doi: 10.1111/echo.13094 contributor: fullname: Cameli – volume: 4 start-page: 277 year: 2016 ident: 2023082310044735600_jead087-B1 article-title: Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2016.01.011 contributor: fullname: Nagueh – volume: 131 start-page: 982 year: 1996 ident: 2023082310044735600_jead087-B3 article-title: Assessment of mitral annular dynamics during diastole by Doppler tissue imaging: comparison with mitral Doppler inflow in subjects without heart disease and in patients with left ventricular hypertrophy publication-title: Am Heart J doi: 10.1016/S0002-8703(96)90183-0 contributor: fullname: Rodriguez – volume: 11 start-page: e006738 year: 2018 ident: 2023082310044735600_jead087-B25 article-title: Impact of ventricular morphology on fiber stress and strain in fontan patients publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.117.006738 contributor: fullname: Ghelani – volume: 76 start-page: 533 year: 2020 ident: 2023082310044735600_jead087-B17 article-title: Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2020.06.007 contributor: fullname: Lala – ident: 2023082310044735600_jead087-B15 contributor: fullname: World Health Organization Scientific Brief |
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We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge... We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from... AIMSWe hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP)... |
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| Title | Left atrial stiffness and strain are novel indices of left ventricular diastolic function in children: validation followed by application in multisystem inflammatory syndrome in children due to COVID-19 |
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