Macrophage activation in vitro by Parachartergus fraternus venom
Parachartergus fraternus wasp induces inflammation with a predominance of mononuclear cells, that can acquire macrophage functions at the sting site, amplifying the response. These cells can be activated by venomous animals and are involved in destruction of injurious agents and release of inflammat...
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| Published in: | Toxicon (Oxford) Vol. 198; pp. 48 - 53 |
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| Abstract | Parachartergus fraternus wasp induces inflammation with a predominance of mononuclear cells, that can acquire macrophage functions at the sting site, amplifying the response. These cells can be activated by venomous animals and are involved in destruction of injurious agents and release of inflammatory mediators. The objective of this work was to evaluate the activity of P. fraternus venom (Pfv) on isolated murine macrophage function. The cells were obtained from peritoneal cavity of Swiss male mice and incubated with Pfv (2.5, 5 and 10 μg/mL). Cytotoxicity was determined using MTT assay. Adhesion and detachment were evaluated using violet crystal dye. Spreading was evaluated based on morphological parameters. Phagocytosis was performed with opsonized zymosan. Production of hydrogen peroxide (H2O2) and nitric oxide (NO) were quantified using the phenol red and Griess assays, respectively. Pfv at concentrations evaluated was not cytotoxic in MTT assay and did not cause macrophage detachment in cell culture plates. However, it increased adhesion of macrophage, spreading and phagocytosis of opsonized zymosan, as well as induced production of H2O2 and NO. Therefore, Pfv induces macrophage activation in vitro and the response of these cells can be correlated with the previously reported inflammatory process triggered by this wasp.
•Parachartergus fraternus venom is not cytotoxic up to 10 μg/mL and it is a pro-inflammatory activator of macrophages.•P. fraternus venom increases adhesion and spreading of macrophages.•P. fraternus venom induces phagocytosis in vitro.•P. fraternus venom induces nitric oxide and hydrogen peroxide production by macrophages. |
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| AbstractList | Parachartergus fraternus wasp induces inflammation with a predominance of mononuclear cells, that can acquire macrophage functions at the sting site, amplifying the response. These cells can be activated by venomous animals and are involved in destruction of injurious agents and release of inflammatory mediators. The objective of this work was to evaluate the activity of P. fraternus venom (Pfv) on isolated murine macrophage function. The cells were obtained from peritoneal cavity of Swiss male mice and incubated with Pfv (2.5, 5 and 10 μg/mL). Cytotoxicity was determined using MTT assay. Adhesion and detachment were evaluated using violet crystal dye. Spreading was evaluated based on morphological parameters. Phagocytosis was performed with opsonized zymosan. Production of hydrogen peroxide (H
O
) and nitric oxide (NO) were quantified using the phenol red and Griess assays, respectively. Pfv at concentrations evaluated was not cytotoxic in MTT assay and did not cause macrophage detachment in cell culture plates. However, it increased adhesion of macrophage, spreading and phagocytosis of opsonized zymosan, as well as induced production of H
O
and NO. Therefore, Pfv induces macrophage activation in vitro and the response of these cells can be correlated with the previously reported inflammatory process triggered by this wasp. Parachartergus fraternus wasp induces inflammation with a predominance of mononuclear cells, that can acquire macrophage functions at the sting site, amplifying the response. These cells can be activated by venomous animals and are involved in destruction of injurious agents and release of inflammatory mediators. The objective of this work was to evaluate the activity of P. fraternus venom (Pfv) on isolated murine macrophage function. The cells were obtained from peritoneal cavity of Swiss male mice and incubated with Pfv (2.5, 5 and 10 μg/mL). Cytotoxicity was determined using MTT assay. Adhesion and detachment were evaluated using violet crystal dye. Spreading was evaluated based on morphological parameters. Phagocytosis was performed with opsonized zymosan. Production of hydrogen peroxide (H2O2) and nitric oxide (NO) were quantified using the phenol red and Griess assays, respectively. Pfv at concentrations evaluated was not cytotoxic in MTT assay and did not cause macrophage detachment in cell culture plates. However, it increased adhesion of macrophage, spreading and phagocytosis of opsonized zymosan, as well as induced production of H2O2 and NO. Therefore, Pfv induces macrophage activation in vitro and the response of these cells can be correlated with the previously reported inflammatory process triggered by this wasp. •Parachartergus fraternus venom is not cytotoxic up to 10 μg/mL and it is a pro-inflammatory activator of macrophages.•P. fraternus venom increases adhesion and spreading of macrophages.•P. fraternus venom induces phagocytosis in vitro.•P. fraternus venom induces nitric oxide and hydrogen peroxide production by macrophages. |
| Author | Souza, Maria Inês Lenz Mortari, Márcia Renata Lencina, Joyce dos Santos Muller, Jéssica de Araujo Isaias Toffoli-Kadri, Mônica Cristina |
| Author_xml | – sequence: 1 givenname: Jéssica de Araujo Isaias surname: Muller fullname: Muller, Jéssica de Araujo Isaias organization: Laboratory of Pharmacology and Inflammation, FACFAN/Federal University of Mato Grosso do Sul, Brazil – sequence: 2 givenname: Joyce dos Santos orcidid: 0000-0002-2520-8356 surname: Lencina fullname: Lencina, Joyce dos Santos organization: Laboratory of Pharmacology and Inflammation, FACFAN/Federal University of Mato Grosso do Sul, Brazil – sequence: 3 givenname: Maria Inês Lenz surname: Souza fullname: Souza, Maria Inês Lenz organization: Laboratory of Biophysiopharmacology, INBIO/ Federal University of Mato Grosso do Sul, Brazil, CB/University of Brasilia, Brazil – sequence: 4 givenname: Márcia Renata surname: Mortari fullname: Mortari, Márcia Renata organization: Laboratory of Neuropharmacology, ICB/University of Brasilia, Brazil – sequence: 5 givenname: Mônica Cristina surname: Toffoli-Kadri fullname: Toffoli-Kadri, Mônica Cristina email: monica.kadri@ufms.br organization: Laboratory of Pharmacology and Inflammation, FACFAN/Federal University of Mato Grosso do Sul, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33940047$$D View this record in MEDLINE/PubMed |
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| Keywords | NO Hydrogen peroxide DMSO CO2 NaOH Cytotoxicity ICAM-1 H2O2 MTT NO2 UFMS NF-κB PRR Cell activation RNS iNOS PAMPs PBS Pfv L-NAME Wasp NOS Nitric oxide ROS NaCl SEM Phagocytosis ELISA |
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