Outcome from treatment of Pneumocystis jirovecii pneumonia with co-trimoxazole

A retrospective case-notes audit of 359 HIV-1-infected adult patients with first-episode laboratory-confirmed Pneumocystis jirovecii pneumonia treated with co-trimoxazole (from 1987 adjuvant steroids were used if PaO(2) <9.3 kPa) showed that only 230/359 (64%) patients completed treatment; 104 (2...

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Bibliographic Details
Published in:	International journal of STD & AIDS Vol. 20; no. 9; p. 652
Main Authors:	Fisk, M, Sage, E K, Edwards, S G, Cartledge, J D, Miller, R F
Format:	Journal Article
Language:	English
Published:	England 01-09-2009
Subjects:	Adult AIDS-Related Opportunistic Infections - drug therapy Anti-Infective Agents - therapeutic use Female Humans Male Pneumocystis carinii Pneumonia, Pneumocystis - drug therapy Retrospective Studies Treatment Outcome Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
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Summary:	A retrospective case-notes audit of 359 HIV-1-infected adult patients with first-episode laboratory-confirmed Pneumocystis jirovecii pneumonia treated with co-trimoxazole (from 1987 adjuvant steroids were used if PaO(2) <9.3 kPa) showed that only 230/359 (64%) patients completed treatment; 104 (29%) patients had treatment-limiting toxicity; rash occurred in 4/60 (6.7%) patients in 1985-1988 and in 15/47 (31.9%) in 2005-2008. Twenty-five patients (7%) failed co-trimoxazole treatment. Overall mortality was 13.6% (49/359); mortality among patients who failed co-trimoxazole treatment was 48% (12/25) and by contrast mortality was 4.8% (5/104) among patients with treatment-limiting toxicity.
ISSN:	0956-4624
DOI:	10.1258/ijsa.2009.008470