Overnight Culture Unmasks Glucose-induced Insulin Secretion in Mouse Islets Lacking ATP-sensitive K+ Channels by Improving the Triggering Ca2+ Signal

A current model ascribes glucose-induced insulin secretion to the interaction of a triggering pathway (KATP channel-dependent Ca2+ influx and rise in cytosolic [Ca2+]c) and an amplifying pathway (KATP channel-independent augmentation of secretion without further increase of [Ca2+]c). However, severa...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 282; no. 20; pp. 14768 - 14776
Main Authors:	Szollosi, Andras, Nenquin, Myriam, Henquin, Jean-Claude
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 18-05-2007 American Society for Biochemistry and Molecular Biology
Subjects:	Adenosine Triphosphate - metabolism Animals ATP-Binding Cassette Transporters - metabolism Calcium - metabolism Calcium Signaling - genetics Cells, Cultured Dose-Response Relationship, Drug Glucose - pharmacology Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Islets of Langerhans - metabolism Mice Mice, Knockout Models, Biological Multidrug Resistance-Associated Proteins - deficiency Multidrug Resistance-Associated Proteins - metabolism Potassium Channels - deficiency Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Receptors, Drug Sulfonylurea Receptors Sweetening Agents - pharmacology Time Factors
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