The combined role of clinical, reflectance confocal microscopy and dermoscopy applied to chronic discoid cutaneous lupus and subacutus lupus erythematosus: A case series and literature review

• Published in: Lupus Vol. 30; no. 1; pp. 125 - 133
• Main Authors: Mazzilli, Sara, Vollono, Laura, Diluvio, Laura, Botti, Elisabetta, Costanza, Gaetana, Campione, Elena, Donati, Michele, Prete, Monia di, Orlandi, Augusto, Bianchi, Luca, Gonzalez, Salvador
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-01-2021; Sage Publications Ltd
• Subjects: Confocal microscopy; Cutaneous Lupus Erythematosus; Dermis; Discoid lupus erythematosus; Epidermis; Inflammation; Literature reviews; Lupus; Microscopy; Phenotypes; Reflectance; Skin diseases; Skin lesions; histopathology; dermatopathology; diagnosis; discoid lupus; Histology; confocal microscopy features
• ISSN: 0961-2033; 1477-0962
• DOI: 10.1177/0961203320958141

Main subtypes of cutaneous lupus erythematosus are represented by acute, subacute cutaneous, intermittent and chronic cutaneous lupus erythematosus. Discoid lupus erythematosus represents the most common phenotype of chronic cutaneous lupus erythematosus. The spectrum of clinical manifestations mirrors that of several and distinct histopathological features. Such variability among different CLE subtypes is also observed at dermoscopy. Dermoscopy is nowadays considered an additional valuable method for skin lesions assessment in general dermatology, following and completing the well-known clinical diagnostic steps, such as medical history and clinical examination. In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging tool able to assess the epidermis and upper dermis producing high resolution (horizontal ∼1.25 μm, vertical ∼5 μm), en face tissue sections used for melanocytic and inflammatory evaluation. In this study, we reported dermoscopic and RCM features about 9 patients affected by subacute and chronic lupus erythematosus retrospectively analyzed.