Moxidectin residues in lamb tissues: Development and validation of analytical method by UHPLC-MS/MS
•Novel method for determination of moxidectin residues in lamb tissues by UHPLC-ESI-MS/MS.•Single sample preparation step developed for moxidectin extraction from target tissues.•Incurred samples from all target tissues used in the validation step.•Short chromatographic run (5.0min) per sample.•Reli...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 1072; pp. 390 - 396 |
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| Language: | English |
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Elsevier B.V
01-01-2018
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| Abstract | •Novel method for determination of moxidectin residues in lamb tissues by UHPLC-ESI-MS/MS.•Single sample preparation step developed for moxidectin extraction from target tissues.•Incurred samples from all target tissues used in the validation step.•Short chromatographic run (5.0min) per sample.•Reliable high-throughput method for surveillance of moxidectin in animal tissue.
The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0.1% formic acid (A) and acetonitrile +0.1% formic acid (B) in a linear gradient program. Method validation was performed based on the Commission Decision 2002/657/EC and VICH GL49. To quantify the analyte, matrix-matched analytical curves were constructed with spiked blank tissues, with a limit of quantitation of 5ngg−1 and limit of detection of 1.5ngg−1 for all matrices. The linearity, decision limit, detection capability accuracy, and inter- and intra-day repeatability of the method are reported. The method was successfully applied to incurred lamb tissue samples (muscle, liver, kidney and fat) in a concentration range from 5 to 200μgkg−1, which demonstrated its suitability for monitoring moxidectin residues in lamb tissues in health surveillance programs, as well as for pharmacokinetics and residue depletion studies. |
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| AbstractList | The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0.1% formic acid (A) and acetonitrile +0.1% formic acid (B) in a linear gradient program. Method validation was performed based on the Commission Decision 2002/657/EC and VICH GL49. To quantify the analyte, matrix-matched analytical curves were constructed with spiked blank tissues, with a limit of quantitation of 5ngg
and limit of detection of 1.5ngg
for all matrices. The linearity, decision limit, detection capability accuracy, and inter- and intra-day repeatability of the method are reported. The method was successfully applied to incurred lamb tissue samples (muscle, liver, kidney and fat) in a concentration range from 5 to 200μgkg
, which demonstrated its suitability for monitoring moxidectin residues in lamb tissues in health surveillance programs, as well as for pharmacokinetics and residue depletion studies. •Novel method for determination of moxidectin residues in lamb tissues by UHPLC-ESI-MS/MS.•Single sample preparation step developed for moxidectin extraction from target tissues.•Incurred samples from all target tissues used in the validation step.•Short chromatographic run (5.0min) per sample.•Reliable high-throughput method for surveillance of moxidectin in animal tissue. The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0.1% formic acid (A) and acetonitrile +0.1% formic acid (B) in a linear gradient program. Method validation was performed based on the Commission Decision 2002/657/EC and VICH GL49. To quantify the analyte, matrix-matched analytical curves were constructed with spiked blank tissues, with a limit of quantitation of 5ngg−1 and limit of detection of 1.5ngg−1 for all matrices. The linearity, decision limit, detection capability accuracy, and inter- and intra-day repeatability of the method are reported. The method was successfully applied to incurred lamb tissue samples (muscle, liver, kidney and fat) in a concentration range from 5 to 200μgkg−1, which demonstrated its suitability for monitoring moxidectin residues in lamb tissues in health surveillance programs, as well as for pharmacokinetics and residue depletion studies. The development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). To achieve higher recovery of the analyte from the matrices, a modified QuEChERS method was used for sample preparation. The chromatographic separation was achieved using a Zorbax Eclipse Plus C18 RRHD column with a mobile phase comprising 5mM ammonium formate solution +0.1% formic acid (A) and acetonitrile +0.1% formic acid (B) in a linear gradient program. Method validation was performed based on the Commission Decision 2002/657/EC and VICH GL49. To quantify the analyte, matrix-matched analytical curves were constructed with spiked blank tissues, with a limit of quantitation of 5ngg-1 and limit of detection of 1.5ngg-1 for all matrices. The linearity, decision limit, detection capability accuracy, and inter- and intra-day repeatability of the method are reported. The method was successfully applied to incurred lamb tissue samples (muscle, liver, kidney and fat) in a concentration range from 5 to 200μgkg-1, which demonstrated its suitability for monitoring moxidectin residues in lamb tissues in health surveillance programs, as well as for pharmacokinetics and residue depletion studies. |
| Author | Daniel, Daniela Fernandes, Maria A.M. Monteiro, Alda L.G. Del Bianchi A. Cruz, Michelle de C. Braga, Patricia A. Reyes, Felix G.R. |
| Author_xml | – sequence: 1 givenname: Michelle surname: Del Bianchi A. Cruz fullname: Del Bianchi A. Cruz, Michelle organization: Department of Food Science, School of Food Engineering, University of Campinas − UNICAMP, Rua Monteiro Lobato, 80, 13083-862, Campinas, SP, Brazil – sequence: 2 givenname: Maria A.M. surname: Fernandes fullname: Fernandes, Maria A.M. organization: Department of Animal Science, Sheep and Goat Production and Research Center (LAPOC), Universidade Federal do Paraná, Rua dos Funcionários, 1540, CEP 80035-050, Curitiba, PR, Brazil – sequence: 3 givenname: Patricia A. surname: de C. Braga fullname: de C. Braga, Patricia A. organization: Department of Food Science, School of Food Engineering, University of Campinas − UNICAMP, Rua Monteiro Lobato, 80, 13083-862, Campinas, SP, Brazil – sequence: 4 givenname: Alda L.G. surname: Monteiro fullname: Monteiro, Alda L.G. organization: Department of Animal Science, Sheep and Goat Production and Research Center (LAPOC), Universidade Federal do Paraná, Rua dos Funcionários, 1540, CEP 80035-050, Curitiba, PR, Brazil – sequence: 5 givenname: Daniela surname: Daniel fullname: Daniel, Daniela organization: Agilent Technologies Brasil, Alameda Araguaia 1142, (Alphaville Industrial), CEP 06455-000, Barueri, SP, Brazil – sequence: 6 givenname: Felix G.R. surname: Reyes fullname: Reyes, Felix G.R. email: reyesfgr@gmail.com organization: Department of Food Science, School of Food Engineering, University of Campinas − UNICAMP, Rua Monteiro Lobato, 80, 13083-862, Campinas, SP, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29241059$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1080_19440049_2018_1465207 crossref_primary_10_3390_molecules27030998 crossref_primary_10_1002_bmc_5814 crossref_primary_10_5851_kosfa_2019_e65 crossref_primary_10_1080_10826076_2021_1995743 crossref_primary_10_18596_jotcsa_1257065 |
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| Keywords | Residues determination Moxidectin UHPLC-MS/MS Lamb tissues QuEChERS |
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| Title | Moxidectin residues in lamb tissues: Development and validation of analytical method by UHPLC-MS/MS |
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