Circular dichroism studies of carbopeptoid-cyclodextrins

• Published in: Chirality (New York, N.Y.) Vol. 17; no. S1; pp. S114 - S119
• Main Authors: Edwards, Alison A., Fleet, George W.J., Mayes, Ben A., Hunter, Stuart J., Tranter, George E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 2005
• Subjects: binding; circular dichroism; CPCD; sugar amino acids
• ISSN: 0899-0042; 1520-636X
• DOI: 10.1002/chir.20117

A series of sugar amino acids, based on open chain sugars, have been oligomerised and cyclised. The resulting cyclic carbopeptoids have been examined for desirable properties such as host–guest chemistry (as in cyclodextrins) or self‐assembling properties (e.g., peptide nanotubes). Initial studies of these systems, by circular dichroism and X‐ray crystallography, have given valuable insight into their stability and properties. One of the four cyclic species studied was found to interact with ion/molecular probes. Chirality 17:S114–S119, 2005. © 2005 Wiley‐Liss, Inc.