Unlocking protein-based biomarker potential for graft-versus-host disease following allogenic hematopoietic stem cell transplants

Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). Risk st...

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Published in:Frontiers in immunology Vol. 15; p. 1327035
Main Authors: Iacobescu, Maria, Pop, Cristina, Uifălean, Alina, Mogoşan, Cristina, Cenariu, Diana, Zdrenghea, Mihnea, Tănase, Alina, Bergthorsson, Jon Thor, Greiff, Victor, Cenariu, Mihai, Iuga, Cristina Adela, Tomuleasa, Ciprian, Tătaru, Dan
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 2024
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Summary:Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). Risk stratification prior to symptom manifestation, along with precise diagnosis and prognosis, relies heavily on clinical features. A critical imperative is the development of tools capable of early identification and effective management of patients undergoing allo-HSCT. A promising avenue in this pursuit is the utilization of proteomics-based biomarkers obtained from non-invasive biospecimens. This review comprehensively outlines the application of proteomics and proteomics-based biomarkers in GVHD patients. It delves into both single protein markers and protein panels, offering insights into their relevance in acute and chronic GVHD. Furthermore, the review provides a detailed examination of the site-specific involvement of GVHD. In summary, this article explores the potential of proteomics as a tool for timely and accurate intervention in the context of GVHD following allo-HSCT.
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ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1327035