Efficacy of milbemycin oxime against naturally acquired or experimentally induced Ancylostoma spp and Trichuris vulpis infections in dogs

• Published in: American journal of veterinary research Vol. 53; no. 4; p. 513
• Main Authors: Blagburn, B L, Hendrix, C M, Lindsay, D S, Vaughan, J L, Hepler, D I, Wright, J C
• Format: Journal Article
• Language: English
• Published: United States 01-04-1992
• Subjects: Ancylostomiasis - drug therapy; Ancylostomiasis - veterinary; Animals; Anthelmintics - therapeutic use; Anti-Bacterial Agents - therapeutic use; Dog Diseases - drug therapy; Dogs; Feces - parasitology; Female; Intestinal Diseases, Parasitic - drug therapy; Intestinal Diseases, Parasitic - veterinary; Macrolides; Male; Parasite Egg Count - veterinary; Trichuriasis - drug therapy; Trichuriasis - veterinary
• DOI: 10.2460/ajvr.1991.53.04.513
• ISSN: 0002-9645

The efficacy of milbemycin oxime was evaluated at dosages of 0.25, 0.50, and 0.75 mg/kg of body weight in dogs naturally infected with mature Ancylostoma spp, at a dosage of 0.50 mg/kg in dogs with experimentally induced immature and mature A caninum, and at dosages of 0.55 to 0.86 mg/kg in dogs naturally infected with mature Trichuris vulpis. Milbemycin oxime was 95 and 99% effective against mature Ancylostoma spp at dosages of 0.50 and 0.75 mg/kg, respectively, but only 49% effective at a dosage of 0.25 mg/kg. Efficacy was 49% against pulmonary L3-L4 stages of A caninum (36 hours after inoculation), greater than 80% against L4 (120 hours after inoculation) and early L5 stages (216 hours after inoculation), and greater than 90% against experimentally induced mature stages (360 hours after inoculation). Milbemycin oxime was also 97% effective in the removal of mature Tr vulpis from naturally infected dogs. Adverse reactions were not observed following treatment in any of the dogs.