Measurement of the apparent diffusion coefficient in paediatric mitochondrial encephalopathy cases and a comparison of parenchymal changes associated with the disease using follow-up diffusion coefficient measurements

• Published in: European journal of radiology Vol. 83; no. 1; pp. 212 - 218
• Main Authors: Uysal, Fatma, Çakmakçı, Handan, Yiş, Uluç, Ellidokuz, Hülya, Hız, Ayşe Semra
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-01-2014
• Subjects: Algorithms; Brain - pathology; Brain ADC; Child; Child, Preschool; Diffusion Magnetic Resonance Imaging - methods; Diffusion-weighted magnetic resonance imaging; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Infant; Magnetic resonance imaging; Male; Mitochondrial Encephalomyopathies - pathology; Mitochondrial encephalopathy; Radiology; Reproducibility of Results; Sensitivity and Specificity; Magnetic resonance imaging; Diffusion-weighted magnetic resonance imaging; Mitochondrial encephalopathy; Brain ADC
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2013.06.031

Highlights • DWI complements conventional MRI in diagnosing mitochondrial encephalopathy (ME) in paediatric patients. • DWI can determine lesion degeneration rate in regions with no signal change. • DWI is useful in the follow-up of ME progression. • Apparent diffusion coefficient (ADC) values can indicate in-lesion degeneration and ME progression. • ADC measurement should be included in routine brain MRI examination.