Recent Advances in Nanoparticle-Mediated Treatment of Inflammatory Bowel Diseases

• Published in: Applied sciences Vol. 11; no. 1; p. 438
• Main Authors: Nedelcu, Andreea, Mosteanu, Ofelia, Pop, Teodora, Mocan, Teodora, Mocan, Lucian
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-01-2021
• Subjects: Biomedical engineering; Colon; Computer applications; Crohn's disease; Drug delivery; Drug delivery systems; Drug dosages; Drug therapy; Health services; Immune response; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Microbiota; Nanomaterials; Nanoparticles; Nanotechnology; Patients; Pharmacodynamics; Remission; Transmission electron microscopy; Ulcerative colitis
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app11010438

There have been continuous advances in nanoscience since the beginning of the 21st century, and the emerging field of computational nanomedicine, the development of nanomaterial-based sensors or the prominent biomedical engineering applications should be mentioned. Intestinal disorders causing prolonged inflammation of the digestive tract, largely known as inflammatory bowel disease (IBD), include Crohn’s disease (CD) and ulcerative colitis (UC), have seen a significant increase in incidence rates. Nanoparticle-based approaches to locally target therapy could help regulate immune responses and act as an anti-inflammatory in individual patients diagnosed with IBD. The results of the paper emphasize the major role that nanoparticle-mediated drug delivery has in IBD treatment, giving IBD patients in remission the chance for a more effective drug therapy with a decreased medication load.