Spectral-Domain and Swept-Source OCT Angiographic Scans Yield Similar Drusen Measurements When Processed with the Same Algorithm
An algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans. Retrospective study. Forty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen....
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| Published in: | Ophthalmology science (Online) Vol. 4; no. 3; p. 100424 |
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| Main Authors: | , , , , , , , , , |
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| Abstract | An algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans.
Retrospective study.
Forty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen.
Patients underwent both SD-OCTA and SS-OCTA imaging at the same visit using the 6 mm × 6 mm OCTA scan patterns. Using the same algorithm, we obtained drusen area and volume measurements within both 3 mm and 5 mm fovea-centered circles. Paired 2-sample
-tests were performed along with Pearson's correlation tests.
Mean square root (sqrt) drusen area and cube root (cbrt) drusen volume within the 3 mm and 5 mm fovea-centered circles.
Mean sqrt drusen area values from SD-OCTA and SS-OCTA scans were 1.57 (standard deviation [SD] 0.57) mm and 1.49 (SD 0.58) mm in the 3 mm circle and 1.88 (SD 0.59) mm and 1.76 (SD 0.58) mm in the 5 mm circle, respectively. Mean cbrt drusen volume measurements were 0.54 (SD 0.19) mm and 0.51 (SD 0.20) mm in the 3 mm circle, and 0.60 (SD 0.17) mm and 0.57 (SD 0.17) mm in the 5 mm circle. Small differences in area and volume measurements were found (all
< 0.001); however, the correlations between the instruments were strong (all coefficients > 0.97; all
< 0.001).
An algorithm originally developed for SS-OCTA scans performs well when used to obtain drusen volume and area measurements from SD-OCTA scans; thus, a separate SD-OCT structural scan is unnecessary to obtain measurements of drusen.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
|---|---|
| AbstractList | An algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans.
Retrospective study.
Forty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen.
Patients underwent both SD-OCTA and SS-OCTA imaging at the same visit using the 6 mm × 6 mm OCTA scan patterns. Using the same algorithm, we obtained drusen area and volume measurements within both 3 mm and 5 mm fovea-centered circles. Paired 2-sample
-tests were performed along with Pearson's correlation tests.
Mean square root (sqrt) drusen area and cube root (cbrt) drusen volume within the 3 mm and 5 mm fovea-centered circles.
Mean sqrt drusen area values from SD-OCTA and SS-OCTA scans were 1.57 (standard deviation [SD] 0.57) mm and 1.49 (SD 0.58) mm in the 3 mm circle and 1.88 (SD 0.59) mm and 1.76 (SD 0.58) mm in the 5 mm circle, respectively. Mean cbrt drusen volume measurements were 0.54 (SD 0.19) mm and 0.51 (SD 0.20) mm in the 3 mm circle, and 0.60 (SD 0.17) mm and 0.57 (SD 0.17) mm in the 5 mm circle. Small differences in area and volume measurements were found (all
< 0.001); however, the correlations between the instruments were strong (all coefficients > 0.97; all
< 0.001).
An algorithm originally developed for SS-OCTA scans performs well when used to obtain drusen volume and area measurements from SD-OCTA scans; thus, a separate SD-OCT structural scan is unnecessary to obtain measurements of drusen.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Purpose: An algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans. Design: Retrospective study. Participants: Forty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen. Methods: Patients underwent both SD-OCTA and SS-OCTA imaging at the same visit using the 6 mm × 6 mm OCTA scan patterns. Using the same algorithm, we obtained drusen area and volume measurements within both 3 mm and 5 mm fovea-centered circles. Paired 2-sample t-tests were performed along with Pearson’s correlation tests. Main Outcome Measures: Mean square root (sqrt) drusen area and cube root (cbrt) drusen volume within the 3 mm and 5 mm fovea-centered circles. Results: Mean sqrt drusen area values from SD-OCTA and SS-OCTA scans were 1.57 (standard deviation [SD] 0.57) mm and 1.49 (SD 0.58) mm in the 3 mm circle and 1.88 (SD 0.59) mm and 1.76 (SD 0.58) mm in the 5 mm circle, respectively. Mean cbrt drusen volume measurements were 0.54 (SD 0.19) mm and 0.51 (SD 0.20) mm in the 3 mm circle, and 0.60 (SD 0.17) mm and 0.57 (SD 0.17) mm in the 5 mm circle. Small differences in area and volume measurements were found (all P < 0.001); however, the correlations between the instruments were strong (all coefficients > 0.97; all P < 0.001). Conclusions: An algorithm originally developed for SS-OCTA scans performs well when used to obtain drusen volume and area measurements from SD-OCTA scans; thus, a separate SD-OCT structural scan is unnecessary to obtain measurements of drusen. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. An algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans.PurposeAn algorithm developed to obtain drusen area and volume measurements using swept-source OCT angiography (SS-OCTA) scans was tested on spectral-domain OCT angiography (SD-OCTA) scans.Retrospective study.DesignRetrospective study.Forty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen.ParticipantsForty pairs of scans from 27 eyes with intermediate age-related macular degeneration and drusen.Patients underwent both SD-OCTA and SS-OCTA imaging at the same visit using the 6 mm × 6 mm OCTA scan patterns. Using the same algorithm, we obtained drusen area and volume measurements within both 3 mm and 5 mm fovea-centered circles. Paired 2-sample t-tests were performed along with Pearson's correlation tests.MethodsPatients underwent both SD-OCTA and SS-OCTA imaging at the same visit using the 6 mm × 6 mm OCTA scan patterns. Using the same algorithm, we obtained drusen area and volume measurements within both 3 mm and 5 mm fovea-centered circles. Paired 2-sample t-tests were performed along with Pearson's correlation tests.Mean square root (sqrt) drusen area and cube root (cbrt) drusen volume within the 3 mm and 5 mm fovea-centered circles.Main Outcome MeasuresMean square root (sqrt) drusen area and cube root (cbrt) drusen volume within the 3 mm and 5 mm fovea-centered circles.Mean sqrt drusen area values from SD-OCTA and SS-OCTA scans were 1.57 (standard deviation [SD] 0.57) mm and 1.49 (SD 0.58) mm in the 3 mm circle and 1.88 (SD 0.59) mm and 1.76 (SD 0.58) mm in the 5 mm circle, respectively. Mean cbrt drusen volume measurements were 0.54 (SD 0.19) mm and 0.51 (SD 0.20) mm in the 3 mm circle, and 0.60 (SD 0.17) mm and 0.57 (SD 0.17) mm in the 5 mm circle. Small differences in area and volume measurements were found (all P < 0.001); however, the correlations between the instruments were strong (all coefficients > 0.97; all P < 0.001).ResultsMean sqrt drusen area values from SD-OCTA and SS-OCTA scans were 1.57 (standard deviation [SD] 0.57) mm and 1.49 (SD 0.58) mm in the 3 mm circle and 1.88 (SD 0.59) mm and 1.76 (SD 0.58) mm in the 5 mm circle, respectively. Mean cbrt drusen volume measurements were 0.54 (SD 0.19) mm and 0.51 (SD 0.20) mm in the 3 mm circle, and 0.60 (SD 0.17) mm and 0.57 (SD 0.17) mm in the 5 mm circle. Small differences in area and volume measurements were found (all P < 0.001); however, the correlations between the instruments were strong (all coefficients > 0.97; all P < 0.001).An algorithm originally developed for SS-OCTA scans performs well when used to obtain drusen volume and area measurements from SD-OCTA scans; thus, a separate SD-OCT structural scan is unnecessary to obtain measurements of drusen.ConclusionsAn algorithm originally developed for SS-OCTA scans performs well when used to obtain drusen volume and area measurements from SD-OCTA scans; thus, a separate SD-OCT structural scan is unnecessary to obtain measurements of drusen.Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.Financial DisclosuresProprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
| ArticleNumber | 100424 |
| Author | O'Brien, Robert C Shen, Mengxi Liu, Jeremy Y Gregori, Giovanni Rosenfeld, Philip J Li, Jianqing Hiya, Farhan E Zhang, Qinqin de Sisternes, Luis Herrera, Gissel |
| Author_xml | – sequence: 1 givenname: Farhan E surname: Hiya fullname: Hiya, Farhan E organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 2 givenname: Jeremy Y surname: Liu fullname: Liu, Jeremy Y organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 3 givenname: Mengxi surname: Shen fullname: Shen, Mengxi organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 4 givenname: Gissel surname: Herrera fullname: Herrera, Gissel organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 5 givenname: Jianqing surname: Li fullname: Li, Jianqing organization: Department of Ophthalmology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China – sequence: 6 givenname: Qinqin surname: Zhang fullname: Zhang, Qinqin organization: Research and Development, Carl Zeiss Meditec, Inc., Dublin, California – sequence: 7 givenname: Luis surname: de Sisternes fullname: de Sisternes, Luis organization: Research and Development, Carl Zeiss Meditec, Inc., Dublin, California – sequence: 8 givenname: Robert C surname: O'Brien fullname: O'Brien, Robert C organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 9 givenname: Philip J surname: Rosenfeld fullname: Rosenfeld, Philip J organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida – sequence: 10 givenname: Giovanni surname: Gregori fullname: Gregori, Giovanni organization: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida |
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| Cites_doi | 10.1016/j.ophtha.2016.01.034 10.1016/j.ajo.2021.10.032 10.1167/tvst.6.1.12 10.1001/archopht.121.4.519 10.1126/scitranslmed.aat4544 10.1016/j.ajo.2020.08.045 10.1364/BOE.449314 10.1167/iovs.15-18572 10.1016/j.ophtha.2010.11.013 10.1167/tvst.10.4.11 10.1016/j.ophtha.2017.09.028 10.1364/BOE.398222 10.1167/iovs.11-7640 10.1167/iovs.12-11569 10.1016/j.ophtha.2011.05.008 10.1167/iovs.14-15273 10.1016/j.ophtha.2018.08.017 10.1038/s41572-021-00265-2 10.1016/j.ophtha.2012.10.036 10.1016/j.ajo.2022.08.012 10.3928/23258160-20131217-01 10.1167/iovs.10-5288 10.1364/BOE.467623 |
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| Keywords | Drusen Age-related macular degeneration (AMD) Spectral-domain OCT angiography (SD-OCTA) Swept-source OCT angiography (SS-OCTA) Retinal pigment epithelial (RPE) elevation |
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| SubjectTerms | Age-related macular degeneration (AMD) Drusen Retinal pigment epithelial (RPE) elevation Spectral-domain OCT angiography (SD-OCTA) Swept-source OCT angiography (SS-OCTA) |
| Title | Spectral-Domain and Swept-Source OCT Angiographic Scans Yield Similar Drusen Measurements When Processed with the Same Algorithm |
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