Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice

Listeria monocytogenes (LM), a facultative intracellular Gram-positive bacterium, often causes lethal infection of the host. In this study we investigated the molecular mechanism underlying LM eradication in the early phase of infection. Upon infection with LM, both IL-12 and IL-18 were produced, an...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 169; no. 7; pp. 3863 - 3868
Main Authors:	Seki, Ekihiro, Tsutsui, Hiroko, Tsuji, Noriko M, Hayashi, Nobuki, Adachi, Keishi, Nakano, Hiroki, Futatsugi-Yumikura, Shizue, Takeuchi, Osamu, Hoshino, Katsuaki, Akira, Shizuo, Fujimoto, Jiro, Nakanishi, Kenji
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-10-2002
Subjects:	Adaptor Proteins, Signal Transducing Animals Antigens, Differentiation - physiology Cytokines - metabolism Drosophila Proteins Female Immunity, Innate - genetics Inflammation - genetics Inflammation - immunology Inflammation - microbiology Interferon-gamma - biosynthesis Interleukin-12 - deficiency Interleukin-12 - genetics Interleukin-12 - metabolism Interleukin-12 - physiology Interleukin-18 - deficiency Interleukin-18 - genetics Interleukin-18 - physiology Listeria monocytogenes - growth & development Listeria monocytogenes - immunology Listeriosis - genetics Listeriosis - immunology Listeriosis - microbiology Listeriosis - pathology Liver - immunology Liver - microbiology Liver - pathology Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Myeloid Differentiation Factor 88 Neutrophil Infiltration - genetics Neutrophil Infiltration - immunology Receptors, Cell Surface - physiology Receptors, Immunologic - physiology Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors Tumor Necrosis Factor-alpha - biosynthesis
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