Ov‐ASP‐1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti‐larval immunity

Summary Vaccination of mice with a recombinant protein, Ov‐ASP‐1, the Onchocerca volvulus homologue of the activation associated secreted gene family stimulated very high titres of both IgG1 and IgG2a without adjuvant. rOv‐ASP‐1 was also immuno‐reactive with IgG isotypes from both O. volvulus‐infect...

Full description

Saved in:

Bibliographic Details
Published in:	Parasite immunology Vol. 26; no. 1; pp. 53 - 62
Main Authors:	MacDonald, A. J., Tawe, W., Leon, O., Cao, L., Liu, J., Oksov, Y., Abraham, D., Lustigman, S.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-01-2004
Subjects:	adjuvant Adjuvants, Immunologic Aluminum Hydroxide - immunology Animals Antibodies, Helminth - blood Antigens, Helminth - genetics Antigens, Helminth - immunology Antigens, Helminth - metabolism Cell Culture Techniques Esophagus - metabolism Freund's Adjuvant helminth Helminth Proteins - genetics Helminth Proteins - immunology Helminth Proteins - metabolism Humans Immunoglobulin E - blood Immunoglobulin G - blood Interferon-gamma - analysis Interferon-gamma - biosynthesis Interleukin-5 - analysis Interleukin-5 - biosynthesis Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Mice Mice, Inbred BALB C Onchocerca volvulus Onchocerca volvulus - immunology Onchocerciasis - immunology Onchocerciasis - parasitology Onchocerciasis - prevention & control Recombinant Proteins - immunology Secretory Vesicles - metabolism Th1 Th2 Vaccination vaccine
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!