Rutin and Hesperidin Revoke the Hepatotoxicity Induced by Paclitaxel in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities

Paclitaxel, one of the most effective chemotherapeutic drugs, is used to treat various cancers but it is exceedingly toxic when used long-term and can harm the liver. This study aimed to see if rutin, hesperidin, and their combination could protect male Wistar rats against paclitaxel (Taxol)-induced...

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Bibliographic Details
Published in:	Evidence-based complementary and alternative medicine Vol. 2023; no. 1; p. 2738351
Main Authors:	Ali, Yasmine A., Soliman, Hanan A., Abdel-Gabbar, Mohamed, Ahmed, Noha A., Attia, Kandil A. A., Shalaby, Fatma M., El-Nahass, El-Shaymaa, Ahmed, Osama M.
Format:	Journal Article
Language:	English
Published:	United States Hindawi 2023 Hindawi Limited
Subjects:	Alanine transaminase Alkaline phosphatase Animals Antioxidants Apoptosis Aspartate transaminase Bilirubin Body weight Brain cancer Cancer therapies Caspase-3 Cell division Cell proliferation Chemotherapy Dietary supplements Drug dosages Glutathione peroxidase Hepatotoxicity Hesperidin Inflammation L-Lactate dehydrogenase Lipid peroxidation Liver Metastases Molecular weight Oxidative stress Paclitaxel Pharmaceutical industry Reagents Rutin Tumor necrosis factor-TNF γ-Glutamyltransferase United States > US Spain India
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