AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

AIDS patients who receive zidovudine (AZT) frequently suffer from myopathy. This has been attributed to mitochondrial (mt) damage, and specifically to the loss of mtDNA. This study examines whether AZT causes oxidative damage to DNA in patients and to skeletal muscle mitochondria in mice, and whethe...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 102; no. 1; pp. 4 - 9
Main Authors:	de la Asunción, J G, del Olmo, M L, Sastre, J, Millán, A, Pellín, A, Pallardó, F V, Viña, J
Format:	Journal Article
Language:	English
Published:	United States 01-07-1998
Subjects:	Adult Animals Anti-HIV Agents - adverse effects Antioxidants - pharmacology Ascorbic Acid - pharmacology Deoxyguanosine - analogs & derivatives Deoxyguanosine - urine DNA Damage DNA, Mitochondrial - drug effects Humans Hydrogen Peroxide - metabolism Male Mice Mitochondria, Muscle - drug effects Mitochondria, Muscle - ultrastructure Vitamin E - pharmacology Zidovudine - adverse effects
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