Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers

Genetically determined differences in interleukin-10 (IL-10) and gamma interferon (IFN-gamma) responses in mice correlate with clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IFN-gamma and additional cytokine genes in patients who had recent-onset Chlam...

Full description

Saved in:

Bibliographic Details
Published in:	Infection and immunity Vol. 67; no. 5; pp. 2682 - 2686
Main Authors:	Kotake, S, Schumacher, Jr, H R, Arayssi, T K, Gérard, H C, Branigan, P J, Hudson, A P, Yarboro, C H, Klippel, J H, Wilder, R L
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-05-1999
Series:	Note
Subjects:	Adult Animals Arthritis - genetics Arthritis - immunology Arthritis, Infectious - etiology Arthritis, Infectious - genetics Arthritis, Infectious - immunology Case-Control Studies Chlamydia - genetics Chlamydia - isolation & purification Chlamydia - pathogenicity Chlamydia Infections - etiology Chlamydia Infections - genetics Chlamydia Infections - immunology Cytokines - genetics DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Female Gene Expression Host Response and Inflammation Humans Interferon-gamma - genetics Interleukin-10 - genetics Male Mice Middle Aged RNA, Messenger - genetics RNA, Messenger - metabolism Synovial Membrane - immunology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Genetically determined differences in interleukin-10 (IL-10) and gamma interferon (IFN-gamma) responses in mice correlate with clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IFN-gamma and additional cytokine genes in patients who had recent-onset Chlamydia-associated arthritis (Chl-AA). IL-10 and IFN-gamma mRNA were relatively abundant in recent-onset Chl-AA.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: Institute of Rheumatology, Tokyo Women’s Medical College, Shinjuku-ku, Tokyo 162, Japan. Corresponding author. Mailing address: ARB, NIAMS, NIH, 10 Center Dr. MSC 1820, Bldg. 10, Rm. 9N228, Bethesda, MD 20892-1820. Phone: (301) 496-6499. Fax: (301) 402-0012. E-mail: wilderr@arb.niams.nih.gov.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.67.5.2682-2686.1999