Electrodeposition of polypyrrole-heparin and polypyrrole-hydroxyapatite films

Electrodeposition of polypyrrole-heparin and polypyrrole-hydroxyapatite films

Composite films containing heparin and hydroxyapatite in a polypyrrole (PPY) matrix were electrochemically deposited as monolayers or bi-layers on conductive substrates. The deposition on stainless steel substrates was achieved using a thin prime layer of PPY deposited by anodic electropolymerizatio...

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Bibliographic Details
Published in:Materials letters Vol. 65; no. 4; pp. 681 - 684
Main Authors: Ma, R., Sask, K.N., Shi, C., Brash, J.L., Zhitomirsky, I.
Format: Journal Article
Language:English
Published: Elsevier B.V 28-02-2011
Subjects:
anions
Anodic
anticoagulant activity
Deposition
Electrodeposition
Heparin
Heparins
Hydroxyapatite
Polypyrrole
Polypyrroles
Salicylate
Salicylates
stainless steel
Surface chemistry
Thin films
Salicylate
Electrodeposition
Hydroxyapatite
Heparin
Polypyrrole
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Summary:Composite films containing heparin and hydroxyapatite in a polypyrrole (PPY) matrix were electrochemically deposited as monolayers or bi-layers on conductive substrates. The deposition on stainless steel substrates was achieved using a thin prime layer of PPY deposited by anodic electropolymerization in the presence of salicylate anions, which passivated the substrate surface. The deposition mechanism, film composition and morphology were investigated. The films containing heparin may have improved anticoagulant activity as suggested by their ability to bind antithrombin from plasma.
Bibliography:http://dx.doi.org/10.1016/j.matlet.2010.11.069
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2010.11.069