Chronic fish oil supplementation partially reverses renal alterations in mice fed with a high-fat diet

• Published in: Journal of functional foods Vol. 26; pp. 196 - 207
• Main Authors: Coelho, Isabela, Pequito, Danielle C.T., Borghetti, Gina, Aikawa, Júlia, Yamaguchi, Adriana A., de Brito, Gleisson A.P., Yamazaki, Ricardo K., Scorsato, Anderson P., Fernandes, Luiz Claudio, Coimbra, Terezila Machado, Fernandez, Ricardo
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-10-2016; Elsevier
• Subjects: Fatty acid; Fish oil supplementation; Glucose intolerance; Obesity; Renal function; Renal morphology; Fish oil supplementation; Obesity; Renal morphology; Renal function; Glucose intolerance; Fatty acid
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2016.07.016

•We study the effect of fish oil supplementation on renal morphology and function in a model of obesity induced by a HFD.•We demonstrated alterations in renal haemodynamic, pathophysiological markers, and initial damage (could progress to CKD) in a mouse obesity model.•Fish oil supplementation positively altered the damage and inflammation markers in renal tissue, interfering against renal injury progression induced by obesity.
The objective of this study was to investigate the alterations in renal morphology and function in an animal model of obesity, and to determine the possible effect of fish oil (FO) supplementation on these alterations. Six-week-old male mice were fed during eight weeks with regular rodent chow (R) or a high-fat diet (HFD), 53.09% fat. After this, they were supplemented orally for 30 days with FO. The weight gain of HFD group was almost three times higher than R. Albuminuria induced by HFD was significantly reduced by FO. The reduction in fractional sodium excretion (FENa+) observed in HFD group was reversed by FO. The HFD was able to increase in almost 100% the concentration of TNF-α in renal tissue, an effect reversed by FO. Intrarenal expression of vimentin was significantly higher in tubulointerstitial cells of HFD group, an effect reversed by FO. In summary, FO partially reverses renal alterations induced by an HFD.