Allelic loss of selected tumor suppressor genes in acute lymphoblastic leukemia in children

Defect in function of tumor suppressor genes may lead to initiation/progression of leukemias. RB1, CDKN2A and TP53 gene alterations are found in acute lymphoblastic leukemia (ALL) in children. Data showing a contribution of these alterations to the pathomechanism of leukemias are contradictory and t...

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Bibliographic Details
Published in:	Polish journal of pathology Vol. 64; no. 2; pp. 121 - 128
Main Authors:	Studniak, E, Maloney, E, Ociepa, T, Urasiński, T, Skonieczka, K, Haus, O, Poluha, A, Kowalczyk, J, Zajączek, S
Format:	Journal Article
Language:	English
Published:	Poland Termedia Publishing House 01-06-2013
Subjects:	Adolescent Apoptosis Bone marrow Cell cycle Cell growth Child Child, Preschool Female Gene expression Genes, p16 Genes, p53 - genetics Genes, Tumor Suppressor Humans In Situ Hybridization, Fluorescence Infant Leukemia Loss of Heterozygosity Male Mutation Pediatrics Phosphorylation Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proteins Retinoblastoma Protein - genetics Young Adult
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