The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children

• Published in: Experimental and clinical endocrinology & diabetes Vol. 125; no. 2; p. 86
• Main Authors: Yuca, S A, Cimbek, E A, Şen, Y, Güvenç, O, Vatansev, H, Buğrul, F, Gün, F, Oran, B
• Format: Journal Article
• Language: English
• Published: Germany 01-02-2017
• Subjects: Adolescent; Adult; Aorta - pathology; Asian Continental Ancestry Group; Child; China; Female; Growth Differentiation Factor 15 - blood; Heart Diseases - blood; Heart Diseases - etiology; Heart Diseases - pathology; Humans; Male; Obesity - blood; Obesity - complications; Obesity - pathology
• ISSN: 1439-3646
• DOI: 10.1055/s-0042-114220

Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor- β super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15. MIC-1/GDF15 is associated with cardio metabolic risk in adults.
Identification of obese children at higher risk for cardio metabolic complications is important. The relations of MIC-1/GDF15 to parameters of obesity in children have never been studied.
We measured serum MIC-1/GDF15 concentration in obese children by ELİSA and evaluated its relationship with anthropometric, biochemical and echocardiographic parameters.
No significant difference in serum MIC-1/GDF15 between normal-weight and obese children was observed. MIC-1/GDF15 was positively correlated with CRP, ALT and aortic dimension when normal-weight and obese children were analyzed together.
MIC-1/GDF15 may provide a link between childhood obesity and cardio metabolic complications that will occur in time course. Further work would be required to find out if MIC-1/GDF15 has any role in the early inflammatory, cardiac and metabolic changes in childhood obesity.