Highly efficient asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a thiourea organocatalyst

Highly efficient asymmetric conjugate addition of 5-benzylfurfurals to nitroalkenes using a thiourea organocatalyst

The asymmetric direct bisvinylogous conjugate addition of 5-benzylfurfural derivatives to nitroalkenes using a thiourea organocatalyst resulted in a corresponding ε-regioselective addition products in high yields and up to 95% enantiomeric excess. [Display omitted]

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Bibliographic Details
Published in:Tetrahedron Vol. 75; no. 16; pp. 2431 - 2435
Main Authors: Akutsu, Hiroshi, Nakashima, Kosuke, Hirashima, Shin-ichi, Matsumoto, Hikari, Koseki, Yuji, Miura, Tsuyoshi
Format: Journal Article
Language:English
Published: Elsevier Ltd 19-04-2019
Subjects:
5-Benzylfurfural
Asymmetric conjugate addition
Nitroalkene
Organocatalyst
Thiourea
Thiourea
Asymmetric conjugate addition
5-Benzylfurfural
Organocatalyst
Nitroalkene
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Description
Summary:The asymmetric direct bisvinylogous conjugate addition of 5-benzylfurfural derivatives to nitroalkenes using a thiourea organocatalyst resulted in a corresponding ε-regioselective addition products in high yields and up to 95% enantiomeric excess. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2019.03.013