In vitro antiparasitic activity of new thiosemicarbazones in strains of Trypanosoma cruzi

In this study thiosemicarbazones derivatives of 5-[(trifluoromethyl)phenylthio]-2-furaldehyde were synthesized and evaluated in terms of their efficiency in challenging the growth of epimastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. A number of compounds were sy...

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Bibliographic Details
Published in:	European journal of medicinal chemistry Vol. 87; pp. 23 - 29
Main Authors:	Moreno-Rodríguez, Adriana, Salazar-Schettino, Paz María, Bautista, Juan Luis, Hernández-Luis, Francisco, Torrens, Hugo, Guevara-Gómez, Yolanda, Pina-Canseco, Socorro, Torres, Martha Bucio, Cabrera-Bravo, Margarita, Martinez, Cesar Mendoza, Pérez-Campos, Eduardo
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 24-11-2014
Subjects:	Apoptosis Apoptosis - drug effects Blood Platelets - drug effects Blood Platelets - parasitology Cells, Cultured Chagas Disease - drug therapy Flow Cytometry Humans In Vitro Techniques Molecular Structure Monocytes - drug effects Monocytes - parasitology Platelet activation Platelet Activation - drug effects Structure–activity relationship Thiosemicarbazones Thiosemicarbazones - chemistry Trypanocidal activity Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma cruzi - drug effects Platelet activation Trypanocidal activity Thiosemicarbazones Structure–activity relationship Apoptosis
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