Distinctive roles of PKC delta isozyme in platelet function
Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it...
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| Published in: | Current research in translational medicine Vol. 64; no. 3; pp. 135 - 139 |
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01-07-2016
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| Abstract | Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it has a central yet complex role in platelets such as opposite signaling functions depending on the nature of the agonist, it concentration and pathway. In fact, it has been shown that PKCδ has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCδ has a positive effect on platelet function. Understanding the crucial role of PKCδ in platelet functions is recently emerging in the literature, therefore, further investigations should shed light into its specific role in hemostasis. In this review, we focus on the different roles of PKCδ in platelet activation, aggregation and thrombus formation. |
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| AbstractList | Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it has a central yet complex role in platelets such as opposite signaling functions depending on the nature of the agonist, it concentration and pathway. In fact, it has been shown that PKCδ has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCδ has a positive effect on platelet function. Understanding the crucial role of PKCδ in platelet functions is recently emerging in the literature, therefore, further investigations should shed light into its specific role in hemostasis. In this review, we focus on the different roles of PKCδ in platelet activation, aggregation and thrombus formation. |
| Author | Naya, A. Zaid, Y. Senhaji, N. Oudghiri, M. Kojok, K. Darif, Y. |
| Author_xml | – sequence: 1 givenname: Y. surname: Zaid fullname: Zaid, Y. email: younes_zaid@yahoo.ca organization: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada – sequence: 2 givenname: N. surname: Senhaji fullname: Senhaji, N. email: nezha.senhaji@gmail.com organization: Laboratory of Genetics and Molecular Pathologies (LGPM), Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco – sequence: 3 givenname: Y. orcidid: 0000-0001-5110-8255 surname: Darif fullname: Darif, Y. email: darifyoussef2000@yahoo.fr organization: Laboratory of Physiology and Molecular Genetics, Faculty of Sciences, Hassan II University, Casablanca, Morocco – sequence: 4 givenname: K. surname: Kojok fullname: Kojok, K. email: kevinkojok@outlook.com organization: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada – sequence: 5 givenname: M. surname: Oudghiri fullname: Oudghiri, M. email: mouniaoudghiri@gmail.com organization: Laboratory of Physiology and Molecular Genetics, Faculty of Sciences, Hassan II University, Casablanca, Morocco – sequence: 6 givenname: A. surname: Naya fullname: Naya, A. email: anaya@mabiotech.com organization: Laboratory of Physiology and Molecular Genetics, Faculty of Sciences, Hassan II University, Casablanca, Morocco |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27765273$$D View this record in MEDLINE/PubMed |
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| Keywords | PKC delta Platelets Thrombosis |
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| Title | Distinctive roles of PKC delta isozyme in platelet function |
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