Functional neuroimaging in hearing research and audiology

• Published in: Zeitschrift für medizinische Physik Vol. 31; no. 3; pp. 289 - 304
• Main Author: Uppenkamp, Stefan
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01-08-2021
• Subjects: Acoustic Stimulation; Audiology; Auditory Cortex; Auditory neuroimaging; Functional Neuroimaging; Hearing; Humans; Loudness; MRI; PET; Pitch; Speech perception; Pitch; Loudness; MRI; PET; Auditory neuroimaging; Speech perception
• ISSN: 0939-3889; 1876-4436
• DOI: 10.1016/j.zemedi.2021.03.003

The various methods of medical imaging are essential for many diagnostic issues in clinical routine, e.g., for the diagnostics and localisation of tumorous diseases, or for the clarification of other lesions in the central nervous system. In addition to these classical roles both positron emission tomography (PET) and magnetic resonance imaging (MRI) allow for the investigation of functional processes in the human brain, when used in a specific way. The last 25 years have seen great progress, especially with respect to functional MRI, in terms of the available experimental paradigms as well as the data analysis strategies, so that a directed investigation of neurophysiological correlates of psychoacoustic performance is possible. This covers fundamental measures of sound perception like loudness and pitch, specific audiological symptoms like tinnitus, which often accompanies hearing disorders, but it also includes experiments on speech perception or on virtual acoustic environments. One important aspect common to many auditory neuroimaging studies is the central question at what stage in the human auditory pathway the sensory coding of the incoming sound is transformed into a universal and context-dependent perceptual representation, which is the basis for what we hear. This overview summarises findings from the literature as well as a few studies from our lab, to discuss the possibilities and the limits of the adoption of functional neuroimaging methods in audiology. Up to this stage, most auditory neuroimaging studies have investigated basic processes in normal hearing listeners. However, the hitherto existing results suggest that the methods of auditory functional neuroimaging – possibly complemented by electrophysiological methods like EEG and MEG – have a great potential to contribute to a deeper understanding of the processes and the impact of hearing disorders.