Chemometrics of anisotropic lipophilicity of anticancer androstane derivatives determined by reversed-phase ultra high performance liquid chromatography with polar aprotic and protic modifiers

•RP-UHPLC analysis was done to define chromatographic lipophilicity of androstane derivatives.•Two ULR and ten MLR QSRR models were defined.•Comparison of experimental and in silico lipophilicity was carried out. The research of the use of steroid compounds in the treatment of various types of cance...

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Bibliographic Details

Published in:	Journal of Chromatography A Vol. 1673; p. 463197
Main Authors:	Kovačević, Strahinja, Karadžić Banjac, Milica, Anojčić, Jasmina, Podunavac-Kuzmanović, Sanja, Jevrić, Lidija, Nikolić, Andrea, Savić, Marina, Kuzminac, Ivana
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 21-06-2022
Subjects:	Biologically active steroids Chemometrics Lipophilicity Molecular modeling Quantitative structure retention relationship analysis Quantitative structure retention relationship analysis Biologically active steroids Molecular modeling Chemometrics Lipophilicity
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