Immune response and protection against Lawsonia intracellularis infections in pigs
Lawsonia intracellularis are Gram-negative, obligate intracellular bacteria that cause proliferative enteropathy (PE), an economically important disease for the pig industry. Numerous reviews have been published on the characteristics and pathogenesis of this bacterium since its isolation and taxono...
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| Published in: | Veterinary immunology and immunopathology Vol. 219; p. 109959 |
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| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01-01-2020
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| Abstract | Lawsonia intracellularis are Gram-negative, obligate intracellular bacteria that cause proliferative enteropathy (PE), an economically important disease for the pig industry. Numerous reviews have been published on the characteristics and pathogenesis of this bacterium since its isolation and taxonomic characterization, with most reviews only partially covering how the host immune response develops during infection and the immune correlates of protection. With the development of increasingly more sophisticated immunological assays and tools for the pig, the immune response against L. intracellularis at distinct stages of pathogenesis has been published. In this review, we discuss current knowledge of the pig immune response against L. intracellularis and strategies to achieve immune protection. The immune response is presented in relation to chronological progression of pathological lesions and clinical symptoms, with emphasis on innate immunity and the adaptive humoral and cell-mediated immune response. The aim is to achieve a comprehensive understanding of the host immune response with respect to the stage-dependent cellular and biochemical processes important during PE development. Also, strategies for development of immune protection and new vaccination technologies are discussed in the light of new discoveries in the field. |
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| AbstractList | Lawsonia intracellularis are Gram-negative, obligate intracellular bacteria that cause proliferative enteropathy (PE), an economically important disease for the pig industry. Numerous reviews have been published on the characteristics and pathogenesis of this bacterium since its isolation and taxonomic characterization, with most reviews only partially covering how the host immune response develops during infection and the immune correlates of protection. With the development of increasingly more sophisticated immunological assays and tools for the pig, the immune response against L. intracellularis at distinct stages of pathogenesis has been published. In this review, we discuss current knowledge of the pig immune response against L. intracellularis and strategies to achieve immune protection. The immune response is presented in relation to chronological progression of pathological lesions and clinical symptoms, with emphasis on innate immunity and the adaptive humoral and cell-mediated immune response. The aim is to achieve a comprehensive understanding of the host immune response with respect to the stage-dependent cellular and biochemical processes important during PE development. Also, strategies for development of immune protection and new vaccination technologies are discussed in the light of new discoveries in the field. |
| ArticleNumber | 109959 |
| Author | Wilson, Heather L. Obradovic, Milan R. |
| Author_xml | – sequence: 1 givenname: Milan R. surname: Obradovic fullname: Obradovic, Milan R. organization: Vaccine and Infectious Disease Organization (VIDO)-International Vaccine Centre (InterVac), University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada – sequence: 2 givenname: Heather L. surname: Wilson fullname: Wilson, Heather L. email: heather.wilson@usask.ca organization: Vaccine and Infectious Disease Organization (VIDO)-International Vaccine Centre (InterVac), University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31710909$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_fbio_2022_102340 crossref_primary_10_3390_biology12060879 crossref_primary_10_4142_jvs_23219 crossref_primary_10_1016_j_jia_2023_04_006 crossref_primary_10_3389_fvets_2022_994147 crossref_primary_10_3390_vaccines11121788 crossref_primary_10_3390_vetsci9100536 crossref_primary_10_3389_fvets_2022_1004506 crossref_primary_10_1177_10406387211003551 crossref_primary_10_1016_j_vetmic_2021_109274 |
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| Keywords | Infectious diease Immune response Ileitis Adaptive Lawsonia intracellularis Innate Pig |
| Language | English |
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