Influence of FAZA PET hypoxia and HPV-status for the outcome of head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy: Long-term results from the DAHANCA 24 trial (NCT01017224)

•18F-FAZA imaging was used in a prospective trial of 38 HNSCC patients completing radiotherapy.•Within 5 years of follow-up, nine locoregional treatment failures were observed.•A high tumor-muscle ratio of tracer uptake (TMR ≥1.6) was associated with a higher risk of locoregional failure.•This assoc...

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Bibliographic Details
Published in:	Radiotherapy and oncology Vol. 151; pp. 126 - 133
Main Authors:	Saksø, Mette, Mortensen, Lise Saksø, Primdahl, Hanne, Johansen, Jørgen, Kallehauge, Jesper, Hansen, Christian Rønn, Overgaard, Jens
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-10-2020
Subjects:	Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - radiotherapy Cell Hypoxia FAZA-PET Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - radiotherapy HNSCC Humans Hypoxia Neoplasm Recurrence, Local Nitroimidazoles Outcome Papillomavirus Infections - complications Positron Emission Tomography Computed Tomography Positron-Emission Tomography Prognostic biomarker Prospective Studies Radiopharmaceuticals Site-of-failure Squamous Cell Carcinoma of Head and Neck - diagnostic imaging Squamous Cell Carcinoma of Head and Neck - radiotherapy FAZA-PET Hypoxia Site-of-failure HNSCC Outcome Prognostic biomarker
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