Bioaccessibility and oral immunization efficacy of a chimeric protein vaccine against Ascaris suum

Human ascariasis has been characterized as the most prevalent neglected tropical disease worldwide. There is an urgent need for search to alternative prevention and control methods for ascariasis. Here we aimed to establish a protocol of oral immunization with a previously described chimera protein...

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Published in:	Microbes and infection Vol. 25; no. 3; p. 105042
Main Authors:	Castro, Joseane C., Magalhães, Luisa MD, Almeida, Raquel M., Oliveira, Fabricio MS, Nogueira, Denise S., Gazzinelli-Guimarães, Ana Clara, Kraemer, Lucas, Barbosa, Fernando S., Santos, Flavianne Vieira, Minighin, Elaine C., Bueno, Lilian L., Bartholomeu, Daniella C., Labanca, Renata A., Fujiwara, Ricardo T.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-03-2023
Subjects:	Animals Antigens, Helminth - genetics Ascariasis - prevention & control Ascaris Ascaris suum Humans Immune response Immunization Mice Mucous Oral vaccine Recombinant Fusion Proteins - genetics Vaccines Oral vaccine Immune response Mucous Ascaris
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Abstract	Human ascariasis has been characterized as the most prevalent neglected tropical disease worldwide. There is an urgent need for search to alternative prevention and control methods for ascariasis. Here we aimed to establish a protocol of oral immunization with a previously described chimera protein capable of resist through digestion and induce mucous protection against Ascaris suum infection. Mice were oral immunized with seven doses with one day interval and challenged with A. suum ten days after the last dose. In vitro digestion showed that 64% of chimeric protein was bioaccessible for absorption after digestion. Immunized mice display 66,2% reduction of larval burden in lungs compared to control group. In conclusion we demonstrated that oral immunization with chimera protein protects the host against A. suum larval migration leading to less pronounced histopathological lesions. [Display omitted]
AbstractList	Human ascariasis has been characterized as the most prevalent neglected tropical disease worldwide. There is an urgent need for search to alternative prevention and control methods for ascariasis. Here we aimed to establish a protocol of oral immunization with a previously described chimera protein capable of resist through digestion and induce mucous protection against Ascaris suum infection. Mice were oral immunized with seven doses with one day interval and challenged with A. suum ten days after the last dose. In vitro digestion showed that 64% of chimeric protein was bioaccessible for absorption after digestion. Immunized mice display 66,2% reduction of larval burden in lungs compared to control group. In conclusion we demonstrated that oral immunization with chimera protein protects the host against A. suum larval migration leading to less pronounced histopathological lesions. Human ascariasis has been characterized as the most prevalent neglected tropical disease worldwide. There is an urgent need for search to alternative prevention and control methods for ascariasis. Here we aimed to establish a protocol of oral immunization with a previously described chimera protein capable of resist through digestion and induce mucous protection against Ascaris suum infection. Mice were oral immunized with seven doses with one day interval and challenged with A. suum ten days after the last dose. In vitro digestion showed that 64% of chimeric protein was bioaccessible for absorption after digestion. Immunized mice display 66,2% reduction of larval burden in lungs compared to control group. In conclusion we demonstrated that oral immunization with chimera protein protects the host against A. suum larval migration leading to less pronounced histopathological lesions. [Display omitted]
ArticleNumber	105042
Author	Bueno, Lilian L. Almeida, Raquel M. Bartholomeu, Daniella C. Santos, Flavianne Vieira Nogueira, Denise S. Castro, Joseane C. Kraemer, Lucas Oliveira, Fabricio MS Gazzinelli-Guimarães, Ana Clara Magalhães, Luisa MD Barbosa, Fernando S. Minighin, Elaine C. Fujiwara, Ricardo T. Labanca, Renata A.
Author_xml	– sequence: 1 givenname: Joseane C. surname: Castro fullname: Castro, Joseane C. organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 2 givenname: Luisa MD surname: Magalhães fullname: Magalhães, Luisa MD organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 3 givenname: Raquel M. surname: Almeida fullname: Almeida, Raquel M. organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 4 givenname: Fabricio MS surname: Oliveira fullname: Oliveira, Fabricio MS organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 5 givenname: Denise S. orcidid: 0000-0003-4091-8783 surname: Nogueira fullname: Nogueira, Denise S. organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 6 givenname: Ana Clara surname: Gazzinelli-Guimarães fullname: Gazzinelli-Guimarães, Ana Clara organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 7 givenname: Lucas surname: Kraemer fullname: Kraemer, Lucas organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 8 givenname: Fernando S. surname: Barbosa fullname: Barbosa, Fernando S. organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 9 givenname: Flavianne Vieira surname: Santos fullname: Santos, Flavianne Vieira organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 10 givenname: Elaine C. surname: Minighin fullname: Minighin, Elaine C. organization: Department of Foods, Pharmacy Faculty, Federal University of Minas Gerais, Belo Horizonte 31515200, Brazil – sequence: 11 givenname: Lilian L. surname: Bueno fullname: Bueno, Lilian L. organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 12 givenname: Daniella C. surname: Bartholomeu fullname: Bartholomeu, Daniella C. organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil – sequence: 13 givenname: Renata A. orcidid: 0000-0002-2120-0082 surname: Labanca fullname: Labanca, Renata A. organization: Department of Foods, Pharmacy Faculty, Federal University of Minas Gerais, Belo Horizonte 31515200, Brazil – sequence: 14 givenname: Ricardo T. orcidid: 0000-0002-4713-575X surname: Fujiwara fullname: Fujiwara, Ricardo T. email: fujiwara@icb.ufmg.br organization: Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte 31270901, Brazil
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36075515$$D View this record in MEDLINE/PubMed
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Keywords	Oral vaccine Immune response Mucous Ascaris
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Snippet	Human ascariasis has been characterized as the most prevalent neglected tropical disease worldwide. There is an urgent need for search to alternative...
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SubjectTerms	Animals Antigens, Helminth - genetics Ascariasis - prevention & control Ascaris Ascaris suum Humans Immune response Immunization Mice Mucous Oral vaccine Recombinant Fusion Proteins - genetics Vaccines
Title	Bioaccessibility and oral immunization efficacy of a chimeric protein vaccine against Ascaris suum
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