Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides

A possible ability of twelve new derivatives of known antioxidants trolox (TroH), trolox succinate (TroS), α-tocopheryl succinate (α-TOS) containing nitroxyl radicals (1–12) to protect bacterial cells from spontaneous and peroxide-induced mutagenesis and their cytotoxicity against six different tumo...

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Bibliographic Details
Published in:	European journal of medicinal chemistry Vol. 122; pp. 127 - 137
Main Authors:	Zakharova, Ol’ga D., Frolova, Tat’yana S., Yushkova, Yuliya V., Chernyak, Elena I., Pokrovsky, Andrei G., Pokrovsky, Mikhail A., Morozov, Sergei V., Sinitsina, Ol’ga I., Grigor’ev, Igor A., Nevinsky, Georgy A.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 21-10-2016
Subjects:	alpha-Tocopherol - chemistry alpha-Tocopherol - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Antitumor activity Cell Line, Tumor Chromans - chemistry Chromans - pharmacology Cricetinae Humans Mice Nitrogen Oxides - chemistry Nitroxides Succinic Acid - chemistry Trolox α-tocopheryl succinate TroS α-TOS EPR pNPP TLC HFI α-TOH t-BuO2H Antioxidants TroH ONPG Trolox ROS IC50 Antitumor activity Nitroxides α-tocopheryl succinate
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