TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) stable silencing increases late apoptosis by upregulation of caspase 9 and APAF1 in RPMI8226 multiple myeloma cell line

TP53 Regulated Inhibitor of Apoptosis 1 (TRIAP1) modulates apoptotic pathways preventing the formation of the apoptosome complex. Our group previous study showed that 90% of patients' multiple myeloma (MM) marrow-derived plasma cells present TRIAP1 overexpression as compared to normal plasma ce...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1862; no. 6; pp. 1105 - 1110
Main Authors:	Fook-Alves, Veruska L., de Oliveira, Mariana Bleker, Zanatta, Daniela B., Strauss, Bryan E., Colleoni, Gisele W.B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2016
Subjects:	Apoptosis Apoptotic Protease-Activating Factor 1 - genetics Caspase 9 - genetics Cell Cycle Cell Line, Tumor Gene Expression Regulation, Neoplastic Gene Silencing Humans Intracellular Signaling Peptides and Proteins - genetics Multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - pathology RNA interference TRIAP1 Up-Regulation MM Hsp70 ORF NEAA RNA interference APAF1 shRNA Multiple myeloma TRIAP1 Apoptosis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!