Variants in exon 2 of MED12 gene causes uterine leiomyoma's through over-expression of MMP-9 of ECM pathway

To study the impact of Mediator complex subunit 12 (MED12) gene variants on the encoded protein's function and pathogenic relevance for genesis of uterine leiomyoma's (ULs). Mutational analysis in exon-2 of MED12 gene was performed by PCR amplification and DNA sequencing in 89 clinically d...

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Bibliographic Details
Published in:	Mutation research Vol. 828; p. 111839
Main Authors:	Pandey, Vivek, Jain, Priyanka, Chatterjee, Souradip, Rani, Anjali, Tripathi, Anima, Dubey, Pawan K
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2024
Subjects:	Adult Exons Extracellular Matrix - genetics Extracellular Matrix - metabolism Female Gene Expression Regulation, Neoplastic Humans Leiomyoma - genetics Leiomyoma - metabolism Leiomyoma - pathology Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mediator Complex - genetics Mediator Complex - metabolism Middle Aged Mutation, Missense Uterine Neoplasms - genetics Uterine Neoplasms - metabolism Uterine Neoplasms - pathology MED-12 Uterine leiomyoma’s Exon2 Somatic Mutation
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