Rapid and sensitive multiresidue analysis of pesticides in tobacco using low pressure and traditional gas chromatography tandem mass spectrometry

• Published in: Journal of Chromatography A Vol. 1418; pp. 228 - 232
• Main Authors: Khan, Zareen S., Girame, Rushali, Utture, Sagar C., Ghosh, Rakesh Kumar, Banerjee, Kaushik
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30-10-2015
• Subjects: Gas Chromatography-Mass Spectrometry - methods; GC–MS/MS; Low pressure GC–MS/MS; Method validation; Multiresidue analysis of pesticides in tobacco; Nicotiana - chemistry; Pesticide Residues - analysis; Smoke - analysis; Tandem Mass Spectrometry - methods; GC–MS/MS; Method validation; Multiresidue analysis of pesticides in tobacco; Low pressure GC–MS/MS
• DOI: 10.1016/j.chroma.2015.09.070
• EISSN: 1873-3778
• ISSN: 0021-9673

•A multi-residue analysis method for 259 pesticides in tobacco matrix is reported.•Low pressure and traditional GC–MS/MS parameters were optimized.•This method comprises the largest number of pesticides for tobacco matrix so far.•All the pesticides were estimated with the lowest ever reported LOQs of <2ppb.
Public exposure to pesticide residues through the main/side-stream smoke of tobacco (Nicotiana tabacum L.) is an international concern. This article reports optimization and validation of large-scale multiresidue analysis methods involving low pressure and traditional gas chromatography tandem mass spectrometry in compliance with the guidance residue levels (GRLs) of Cooperative Centre for Scientific Research Relative to Tobacco (CORESTA). Analysis by low pressure GC–MS/MS offered three times rapid turn around time over the traditional GC–MS/MS with limits of quantifications (LOQs) less than 2μg/L for all the 259 test compounds and the recoveries in the range of 70–118% (±20%) at 10 and 20μg/kg levels of fortification.