The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway

[Display omitted] The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway i...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 100; pp. 388 - 393
Main Authors:	Gazola, Andressa Corneo, Costa, Geison Modesti, Zucolotto, Silvana Maria, Castellanos, Leonardo, Ramos, Freddy Alejandro, de Lima, Thereza Christina Monteiro, Schenkel, Eloir Paulo
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-04-2018
Subjects:	Animals C-glycosylflavonoids Diazepam - pharmacology Dose-Response Relationship, Drug Flavonoids - isolation & purification Flavonoids - pharmacology GABA Modulators - pharmacology GABAergic Neurons - drug effects GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Hypnotics and Sedatives - isolation & purification Hypnotics and Sedatives - pharmacology Male Mice Passiflora Passiflora quadrangularis Passifloraceae Passion flower Plant Extracts - isolation & purification Plant Extracts - pharmacology Sedative Signal Transduction - drug effects Signal Transduction - physiology Vitexin-2’’-O-xyloside Passion flower Sedative Passiflora quadrangularis Passifloraceae C-glycosylflavonoids Vitexin-2’’-O-xyloside
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