The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway
[Display omitted] The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway i...
Saved in:
| Published in: | Biomedicine & pharmacotherapy Vol. 100; pp. 388 - 393 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
France
Elsevier Masson SAS
01-04-2018
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | [Display omitted]
The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2’’-O-xyloside, vitexin-2’’-O-glucoside, orientin-2’’-O-xyloside and orientin-2’’-O-glucoside. Vitexin-2”-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice. |
|---|---|
| AbstractList | The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2''-O-xyloside, vitexin-2''-O-glucoside, orientin-2''-O-xyloside and orientin-2''-O-glucoside. Vitexin-2"-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice. [Display omitted] The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated and consumed in South America, and to identify its main constituents and elucidate the involvement of the GABAergic pathway in its mechanism of action. The bioguided fractionation of the crude extract showed a positive relationship between the sedative activity of the extract and its flavonoids. The methods employed to identify and isolate its main flavonoids resulted in the identification of vitexin-2’’-O-xyloside, vitexin-2’’-O-glucoside, orientin-2’’-O-xyloside and orientin-2’’-O-glucoside. Vitexin-2”-O-xyloside, the major flavonoid of the extract, showed sedative activity after oral administration in mice. |
| Author | Schenkel, Eloir Paulo de Lima, Thereza Christina Monteiro Gazola, Andressa Corneo Costa, Geison Modesti Castellanos, Leonardo Zucolotto, Silvana Maria Ramos, Freddy Alejandro |
| Author_xml | – sequence: 1 givenname: Andressa Corneo surname: Gazola fullname: Gazola, Andressa Corneo email: andressa@unibave.net organization: Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, 88040-970, Brazil – sequence: 2 givenname: Geison Modesti surname: Costa fullname: Costa, Geison Modesti email: modesticosta.g@javeriana.edu.co organization: Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, 88040-970, Brazil – sequence: 3 givenname: Silvana Maria surname: Zucolotto fullname: Zucolotto, Silvana Maria email: silvanazucolotto@ufrnet.br organization: Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 59078-970, Brazil – sequence: 4 givenname: Leonardo surname: Castellanos fullname: Castellanos, Leonardo email: lcastellanosh@unal.edu.co organization: Departamento de Química, Universidad Nacional de Colombia, Carrera 30 No.45-03, Bogotá, Colombia – sequence: 5 givenname: Freddy Alejandro surname: Ramos fullname: Ramos, Freddy Alejandro email: faramosr@unal.edu.co organization: Departamento de Química, Universidad Nacional de Colombia, Carrera 30 No.45-03, Bogotá, Colombia – sequence: 6 givenname: Thereza Christina Monteiro surname: de Lima fullname: de Lima, Thereza Christina Monteiro email: thereza.lima@ufsc.br organization: Programa de Pós-graduação em Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, 88040-970, Brazil – sequence: 7 givenname: Eloir Paulo surname: Schenkel fullname: Schenkel, Eloir Paulo email: eloir.schenkel@ufsc.br organization: Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, 88040-970, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29454287$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kE9r3DAUxEVJaTZpv0EpOvZi5-mPJftS2IY2DQTaQ3oWWvlprcVrbSR7w377KmzaY-HBXGbeML8rcjHFCQn5yKBmwNTNrt6EeBhszYG1NfAagL8hK9Y1UCkAfUFWoBtRCcH5JbnKeQcAjRLtO3LJO9lI3uoVGR8HpBl7O4cjUuuKhPlEo6d-tMc4xdBn6lPc01825-DHmCx9Wmyf7LRdRptCpuX22Ac7Y0_nIcVlOxRFerf-usa0DY4e7Dw829N78tbbMeOHV70mv79_e7z9UT38vLu_XT9UTig-V8x12Ai5abWWyJWy2vJuw1WnRYPgpdRdx7wSmoPyzPWqZZqLRvVMgQSnxTX5fP57SPFpwTybfcgOx9FOGJdsOIAA2XKQxSrPVpdizgm9OaSwt-lkGJgXzmZnzpzNC2cD3BTOJfbptWHZlO3_Qn_BFsOXswHLzmPAZLILOLnCKaGbTR_D_xv-AFUTkeA |
| CitedBy_id | crossref_primary_10_1016_j_foodres_2019_01_058 crossref_primary_10_1016_j_indcrop_2024_119002 crossref_primary_10_1016_j_jksus_2022_101886 crossref_primary_10_1002_jsf2_108 crossref_primary_10_2174_1871524922666220426102650 crossref_primary_10_1016_j_foodchem_2023_136825 crossref_primary_10_3390_foods12152889 crossref_primary_10_1016_j_jep_2024_118252 crossref_primary_10_3389_fcimb_2023_1197646 crossref_primary_10_1371_journal_pone_0255059 crossref_primary_10_2174_1568026622666220819160923 crossref_primary_10_1016_j_jep_2021_114746 crossref_primary_10_1016_j_tifs_2022_07_008 crossref_primary_10_1080_10496475_2023_2225147 crossref_primary_10_1055_a_1305_3936 crossref_primary_10_1080_10408398_2020_1753165 crossref_primary_10_3390_nutraceuticals4010005 crossref_primary_10_1055_a_1528_4165 crossref_primary_10_2139_ssrn_4166520 crossref_primary_10_1016_j_foodres_2022_112441 crossref_primary_10_1016_j_jff_2019_103529 crossref_primary_10_1016_j_bjp_2018_06_005 crossref_primary_10_3390_immuno2040043 |
| Cites_doi | 10.1016/S0031-9422(00)94527-8 10.1111/j.1462-2920.2010.02352.x 10.1016/j.bjp.2015.03.009 10.1128/AEM.02115-12 10.1021/np50007a017 10.1002/ptr.3400 10.1002/pca.1348 10.3181/0902-RM-84 10.1016/S0378-8741(97)00042-1 10.1016/j.bbr.2011.02.038 10.1016/j.fitote.2016.09.011 10.1021/np50024a030 10.1590/S0102-695X2012005000108 10.1111/j.1365-2125.2006.02680.x 10.1002/ptr.2079 10.1002/ptr.5043 10.1080/10826076.2012.695316 10.1016/S0031-9422(00)82358-4 10.1016/j.pbb.2006.12.019 10.1016/j.phymed.2010.03.002 10.1039/c3fo60047e 10.1016/j.bjp.2016.02.005 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier Masson SAS Copyright © 2018 Elsevier Masson SAS. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier Masson SAS – notice: Copyright © 2018 Elsevier Masson SAS. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.biopha.2018.02.002 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1950-6007 |
| EndPage | 393 |
| ExternalDocumentID | 10_1016_j_biopha_2018_02_002 29454287 S0753332217358018 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 0SF 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4CK 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFWJ AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABBQC ABFNM ABLVK ABMAC ABMZM ABXDB ABYKQ ABZDS ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFCTW AFKWA AFPKN AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AI. AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA GROUPED_DOAJ HMT HVGLF HZ~ IHE J1W KOM LCYCR M34 M41 MO0 N9A NCXOZ O-L O9- OAUVE OD~ OGGZJ OK1 OO0 OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SDP SEM SES SEW SPT SSH SSP SSZ T5K VH1 WUQ Z5R ~02 ~G- AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c362t-1c9e534b8774e266a7a29b269735e0f447991f637206f1cd68172356d16040c73 |
| ISSN | 0753-3322 |
| IngestDate | Sun Sep 29 07:25:43 EDT 2024 Thu Nov 21 23:38:20 EST 2024 Wed Oct 16 00:59:59 EDT 2024 Fri Feb 23 02:47:36 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Passion flower Sedative Passiflora quadrangularis Passifloraceae C-glycosylflavonoids Vitexin-2’’-O-xyloside |
| Language | English |
| License | Copyright © 2018 Elsevier Masson SAS. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c362t-1c9e534b8774e266a7a29b269735e0f447991f637206f1cd68172356d16040c73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 29454287 |
| PQID | 2003048204 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_2003048204 crossref_primary_10_1016_j_biopha_2018_02_002 pubmed_primary_29454287 elsevier_sciencedirect_doi_10_1016_j_biopha_2018_02_002 |
| PublicationCentury | 2000 |
| PublicationDate | April 2018 2018-Apr 2018-04-00 20180401 |
| PublicationDateYYYYMMDD | 2018-04-01 |
| PublicationDate_xml | – month: 04 year: 2018 text: April 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | France |
| PublicationPlace_xml | – name: France |
| PublicationTitle | Biomedicine & pharmacotherapy |
| PublicationTitleAlternate | Biomed Pharmacother |
| PublicationYear | 2018 |
| Publisher | Elsevier Masson SAS |
| Publisher_xml | – name: Elsevier Masson SAS |
| References | Szabadi (bib0130) 2006; 61 Vanderplank (bib0015) 2000 Gazola, Costa, Castellanos, Ramos, Reginatto, Lima, Schenkel (bib0055) 2015; 25 Costa, Gazola, Zucolotto, Castellanos, Ramos, Reginatto, Schenkel (bib0035) 2016; 26 Ulubelen, Oksuz, Mabry, Dellamonica, Chopin (bib0125) 1982; 45 He, Jw, Wl, Xh, Jx, Peng (bib0135) 2016; 115 Sena, Zucolotto, Reginatto, Schenkel, Lima (bib0060) 2009; 234 Zucolotto, Fagundes, Reginatto, Ramos, Castellanos, Duque, Schenkel (bib0030) 2012; 23 Orsini, Pelizzoni, Verotta (bib0040) 1985; 25 Brasil - Agência Nacional de Vigilância Sanitária (bib0115) 2010 Carvalho, Duarte, Lima (bib0100) 2011; 221 Ulmer, MacDougal (bib0020) 2004 Ulubelen, Mabry (bib0120) 1980; 43 Elsas, Rossib, Raber, White, Seeley, Gregory, Mohr, Pfankuch, Soumyanath (bib0105) 2010; 17 Orsini, Pellizzoni, Ricca, Verotta (bib0045) 1987; 26 Klein, Gazola, Lima, Schenkel, Nieber, Butterweck (bib0090) 2014; 28 EMA (bib0110) 2014 Ngan, Conduit (bib0085) 2011; 25 Markham (bib0065) 1982 Braune, Blaut (bib0145) 2011; 13 Blumenthal, Goldeberg, Brinckmann (bib0010) 2000 Angelino, Berhow, Ninfali, Jeffery (bib0150) 2013; 4 Killip (bib0005) 1938; vol. XIX Castro, Hoshino, Silva, Mendes (bib0050) 2007; 21 Soulimani, Younos, Jarmouni, Bousta, Misslin, Mortier (bib0075) 1997; 57 Duarte, Duzzioni, Mendes, Pizzolatti, Lima (bib0095) 2007; 86 Costa, Gazola, Madóglio, Zucolotto, Reginatto, Castellanos, Ramos, Duque, Schenkel (bib0025) 2013; 36 Braune, Blaut (bib0140) 2012; 78 Provensi, Noël, Lopes, Fenner, Betti, Costa, Morais, Gosmann, Rates (bib0080) 2008; 27 Sakalem, Negri, Tabach (bib0070) 2013; 22 Orsini (10.1016/j.biopha.2018.02.002_bib0045) 1987; 26 Braune (10.1016/j.biopha.2018.02.002_bib0140) 2012; 78 Carvalho (10.1016/j.biopha.2018.02.002_bib0100) 2011; 221 EMA (10.1016/j.biopha.2018.02.002_bib0110) 2014 Soulimani (10.1016/j.biopha.2018.02.002_bib0075) 1997; 57 Costa (10.1016/j.biopha.2018.02.002_bib0035) 2016; 26 Gazola (10.1016/j.biopha.2018.02.002_bib0055) 2015; 25 Angelino (10.1016/j.biopha.2018.02.002_bib0150) 2013; 4 Brasil - Agência Nacional de Vigilância Sanitária (10.1016/j.biopha.2018.02.002_bib0115) 2010 Orsini (10.1016/j.biopha.2018.02.002_bib0040) 1985; 25 Markham (10.1016/j.biopha.2018.02.002_bib0065) 1982 Braune (10.1016/j.biopha.2018.02.002_bib0145) 2011; 13 Zucolotto (10.1016/j.biopha.2018.02.002_bib0030) 2012; 23 Sena (10.1016/j.biopha.2018.02.002_bib0060) 2009; 234 Killip (10.1016/j.biopha.2018.02.002_bib0005) 1938; vol. XIX Ulubelen (10.1016/j.biopha.2018.02.002_bib0125) 1982; 45 Provensi (10.1016/j.biopha.2018.02.002_bib0080) 2008; 27 He (10.1016/j.biopha.2018.02.002_bib0135) 2016; 115 Klein (10.1016/j.biopha.2018.02.002_bib0090) 2014; 28 Elsas (10.1016/j.biopha.2018.02.002_bib0105) 2010; 17 Duarte (10.1016/j.biopha.2018.02.002_bib0095) 2007; 86 Costa (10.1016/j.biopha.2018.02.002_bib0025) 2013; 36 Blumenthal (10.1016/j.biopha.2018.02.002_bib0010) 2000 Sakalem (10.1016/j.biopha.2018.02.002_bib0070) 2013; 22 Ulmer (10.1016/j.biopha.2018.02.002_bib0020) 2004 Castro (10.1016/j.biopha.2018.02.002_bib0050) 2007; 21 Ulubelen (10.1016/j.biopha.2018.02.002_bib0120) 1980; 43 Vanderplank (10.1016/j.biopha.2018.02.002_bib0015) 2000 Szabadi (10.1016/j.biopha.2018.02.002_bib0130) 2006; 61 Ngan (10.1016/j.biopha.2018.02.002_bib0085) 2011; 25 |
| References_xml | – volume: 28 start-page: 706 year: 2014 end-page: 713 ident: bib0090 article-title: Assessment of sedative effects of publication-title: Phytother. Res. contributor: fullname: Butterweck – volume: 25 start-page: 191 year: 1985 end-page: 193 ident: bib0040 article-title: Quadranguloside, a cycloartane triterpene glycoside from publication-title: Phytochemistry contributor: fullname: Verotta – volume: 27 start-page: 845 year: 2008 end-page: 851 ident: bib0080 article-title: Participation of GABA-benzodiazepine receptor complex in the anxiolytic-like effect of publication-title: Lat. Am. J. Pharm. contributor: fullname: Rates – volume: 221 start-page: 75 year: 2011 end-page: 82 ident: bib0100 article-title: Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice publication-title: Behav. Brain Res. contributor: fullname: Lima – volume: 25 start-page: 1153 year: 2011 end-page: 1159 ident: bib0085 article-title: Double‐blind, placebo‐controlled investigation of the effects of publication-title: Phytother. Res. contributor: fullname: Conduit – volume: 78 start-page: 8151 year: 2012 end-page: 8153 ident: bib0140 article-title: Intestinal bacterium publication-title: Appl. Environ. Microbiol. contributor: fullname: Blaut – volume: 61 start-page: 761 year: 2006 end-page: 766 ident: bib0130 article-title: Drugs for sleep disorders: mechanisms and therapeutic prospects publication-title: Br. J. Clin. Pharmacol. contributor: fullname: Szabadi – volume: 13 start-page: 482 year: 2011 end-page: 494 ident: bib0145 article-title: Deglycosylation of puerarin and other aromatic publication-title: Environ. Microbiol. contributor: fullname: Blaut – volume: 17 start-page: 940 year: 2010 end-page: 949 ident: bib0105 article-title: L. (Passionflower) extracts elicit GABA currents in hippocampal neurons publication-title: Phytomedicine contributor: fullname: Soumyanath – volume: 26 start-page: 1101 year: 1987 end-page: 1105 ident: bib0045 article-title: Triterpene glycosides related to quadranguloside from publication-title: Phytochemistry contributor: fullname: Verotta – volume: 26 start-page: 451 year: 2016 end-page: 458 ident: bib0035 article-title: Chemical profiles of traditional preparations of four South American publication-title: Braz. J. Pharmacogn. contributor: fullname: Schenkel – volume: 86 start-page: 150 year: 2007 end-page: 161 ident: bib0095 article-title: Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of publication-title: Pharmacol. Biochem. Behav. contributor: fullname: Lima – year: 2000 ident: bib0010 article-title: Herbal Medicine: Expanded Commission E Monographs contributor: fullname: Brinckmann – volume: 22 start-page: 1219 year: 2013 end-page: 1232 ident: bib0070 article-title: Chemical composition of hydroethanolic extracts from five species of the publication-title: Braz. J. Pharmacogn. contributor: fullname: Tabach – year: 2000 ident: bib0015 article-title: Passion Flowers contributor: fullname: Vanderplank – volume: 234 start-page: 967 year: 2009 end-page: 975 ident: bib0060 article-title: Neuropharmacological activity of the pericarp of publication-title: Exp. Biol. Med. contributor: fullname: Lima – volume: 4 start-page: 1339 year: 2013 end-page: 1345 ident: bib0150 article-title: Caecal absorption of vitexin-2- publication-title: Food Funct. contributor: fullname: Jeffery – year: 2004 ident: bib0020 article-title: : Passionflowers of the World contributor: fullname: MacDougal – volume: 21 start-page: 481 year: 2007 end-page: 484 ident: bib0050 article-title: Possible anxiolytic effect of two extracts of publication-title: Phytother. Res. contributor: fullname: Mendes – volume: 25 start-page: 158 year: 2015 end-page: 163 ident: bib0055 article-title: Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from publication-title: Braz. J. Pharmacogn. contributor: fullname: Schenkel – year: 1982 ident: bib0065 article-title: Techniques of Flavonoids Identification contributor: fullname: Markham – year: 2010 ident: bib0115 article-title: Farmacopeia Brasileira v 2 contributor: fullname: Brasil - Agência Nacional de Vigilância Sanitária – volume: 36 start-page: 1697 year: 2013 end-page: 1907 ident: bib0025 article-title: Vitexin derivatives as chemical markers in the differentiation of the closely related species publication-title: J. Liquid Chromatogr. Relat. Technol. contributor: fullname: Schenkel – volume: 23 start-page: 232 year: 2012 end-page: 239 ident: bib0030 article-title: Analysis of publication-title: Phytochem. Anal. contributor: fullname: Schenkel – volume: 115 start-page: 74 year: 2016 end-page: 85 ident: bib0135 article-title: A review on the pharmacological effects of vitexin and isovitexin publication-title: Fitoterapia contributor: fullname: Peng – volume: vol. XIX year: 1938 ident: bib0005 article-title: The american species of Passifloraceae publication-title: Part II. Botanical Series contributor: fullname: Killip – year: 2014 ident: bib0110 article-title: European Union Herbal Monograph: Assessment Report on contributor: fullname: EMA – volume: 43 start-page: 162 year: 1980 ident: bib0120 article-title: -glycosylflavonoids of Passiflora serratifolia publication-title: J. Nat. Prod. contributor: fullname: Mabry – volume: 45 start-page: 783 year: 1982 ident: bib0125 article-title: -glycosylflavonoids from publication-title: J. Nat. Prod. contributor: fullname: Chopin – volume: 57 start-page: 11 year: 1997 end-page: 20 ident: bib0075 article-title: Behavioural effects of publication-title: J. Ethnopharmacol. contributor: fullname: Mortier – volume: 25 start-page: 191 year: 1985 ident: 10.1016/j.biopha.2018.02.002_bib0040 article-title: Quadranguloside, a cycloartane triterpene glycoside from Passiflora quadrangularis publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)94527-8 contributor: fullname: Orsini – volume: 27 start-page: 845 year: 2008 ident: 10.1016/j.biopha.2018.02.002_bib0080 article-title: Participation of GABA-benzodiazepine receptor complex in the anxiolytic-like effect of Passiflora alata curtis (Passifloraceae) publication-title: Lat. Am. J. Pharm. contributor: fullname: Provensi – year: 2010 ident: 10.1016/j.biopha.2018.02.002_bib0115 contributor: fullname: Brasil - Agência Nacional de Vigilância Sanitária – volume: 13 start-page: 482 year: 2011 ident: 10.1016/j.biopha.2018.02.002_bib0145 article-title: Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2010.02352.x contributor: fullname: Braune – volume: 25 start-page: 158 year: 2015 ident: 10.1016/j.biopha.2018.02.002_bib0055 article-title: Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp publication-title: Braz. J. Pharmacogn. doi: 10.1016/j.bjp.2015.03.009 contributor: fullname: Gazola – volume: 78 start-page: 8151 year: 2012 ident: 10.1016/j.biopha.2018.02.002_bib0140 article-title: Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glucosides publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.02115-12 contributor: fullname: Braune – volume: 43 start-page: 162 year: 1980 ident: 10.1016/j.biopha.2018.02.002_bib0120 article-title: C-glycosylflavonoids of Passiflora serratifolia publication-title: J. Nat. Prod. doi: 10.1021/np50007a017 contributor: fullname: Ulubelen – volume: 25 start-page: 1153 year: 2011 ident: 10.1016/j.biopha.2018.02.002_bib0085 article-title: Double‐blind, placebo‐controlled investigation of the effects of Passiflora incarnata (Passionflower) herbal tea on subjective sleep quality publication-title: Phytother. Res. doi: 10.1002/ptr.3400 contributor: fullname: Ngan – volume: 23 start-page: 232 year: 2012 ident: 10.1016/j.biopha.2018.02.002_bib0030 article-title: Analysis of C-glycosyl flavonoids from South American Passiflora species by HPLC-DAD and HPLC-MS publication-title: Phytochem. Anal. doi: 10.1002/pca.1348 contributor: fullname: Zucolotto – volume: 234 start-page: 967 year: 2009 ident: 10.1016/j.biopha.2018.02.002_bib0060 article-title: Neuropharmacological activity of the pericarp of Passiflora edulis Flavicarpa Degener: putative involvement of C-glycosylflavonoids publication-title: Exp. Biol. Med. doi: 10.3181/0902-RM-84 contributor: fullname: Sena – volume: 57 start-page: 11 year: 1997 ident: 10.1016/j.biopha.2018.02.002_bib0075 article-title: Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse publication-title: J. Ethnopharmacol. doi: 10.1016/S0378-8741(97)00042-1 contributor: fullname: Soulimani – volume: 221 start-page: 75 year: 2011 ident: 10.1016/j.biopha.2018.02.002_bib0100 article-title: Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2011.02.038 contributor: fullname: Carvalho – volume: 115 start-page: 74 year: 2016 ident: 10.1016/j.biopha.2018.02.002_bib0135 article-title: A review on the pharmacological effects of vitexin and isovitexin publication-title: Fitoterapia doi: 10.1016/j.fitote.2016.09.011 contributor: fullname: He – volume: vol. XIX year: 1938 ident: 10.1016/j.biopha.2018.02.002_bib0005 article-title: The american species of Passifloraceae contributor: fullname: Killip – volume: 45 start-page: 783 year: 1982 ident: 10.1016/j.biopha.2018.02.002_bib0125 article-title: C-glycosylflavonoids from Passiflora pittieri, P. alata, P. ambigua and Adenia manii publication-title: J. Nat. Prod. doi: 10.1021/np50024a030 contributor: fullname: Ulubelen – volume: 22 start-page: 1219 year: 2013 ident: 10.1016/j.biopha.2018.02.002_bib0070 article-title: Chemical composition of hydroethanolic extracts from five species of the Passiflora genus publication-title: Braz. J. Pharmacogn. doi: 10.1590/S0102-695X2012005000108 contributor: fullname: Sakalem – year: 2000 ident: 10.1016/j.biopha.2018.02.002_bib0010 contributor: fullname: Blumenthal – year: 2000 ident: 10.1016/j.biopha.2018.02.002_bib0015 contributor: fullname: Vanderplank – volume: 61 start-page: 761 year: 2006 ident: 10.1016/j.biopha.2018.02.002_bib0130 article-title: Drugs for sleep disorders: mechanisms and therapeutic prospects publication-title: Br. J. Clin. Pharmacol. doi: 10.1111/j.1365-2125.2006.02680.x contributor: fullname: Szabadi – year: 2004 ident: 10.1016/j.biopha.2018.02.002_bib0020 contributor: fullname: Ulmer – volume: 21 start-page: 481 year: 2007 ident: 10.1016/j.biopha.2018.02.002_bib0050 article-title: Possible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental models publication-title: Phytother. Res. doi: 10.1002/ptr.2079 contributor: fullname: Castro – volume: 28 start-page: 706 year: 2014 ident: 10.1016/j.biopha.2018.02.002_bib0090 article-title: Assessment of sedative effects of Passiflora edulis f. flavicarpa and Passiflora alata extracts in mice, measured by telemetry publication-title: Phytother. Res. doi: 10.1002/ptr.5043 contributor: fullname: Klein – year: 2014 ident: 10.1016/j.biopha.2018.02.002_bib0110 contributor: fullname: EMA – year: 1982 ident: 10.1016/j.biopha.2018.02.002_bib0065 contributor: fullname: Markham – volume: 36 start-page: 1697 year: 2013 ident: 10.1016/j.biopha.2018.02.002_bib0025 article-title: Vitexin derivatives as chemical markers in the differentiation of the closely related species Passiflora alata Curtis. and Passiflora quadrangularis Linn publication-title: J. Liquid Chromatogr. Relat. Technol. doi: 10.1080/10826076.2012.695316 contributor: fullname: Costa – volume: 26 start-page: 1101 year: 1987 ident: 10.1016/j.biopha.2018.02.002_bib0045 article-title: Triterpene glycosides related to quadranguloside from Passiflora quadrangularis publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)82358-4 contributor: fullname: Orsini – volume: 86 start-page: 150 year: 2007 ident: 10.1016/j.biopha.2018.02.002_bib0095 article-title: Participation of dihydrostyryl-2-pyrones and styryl-2-pyrones in the central effects of Polygala sabulosa (Polygalaceae) a folk medicine topical anesthetic publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/j.pbb.2006.12.019 contributor: fullname: Duarte – volume: 17 start-page: 940 issue: 12 year: 2010 ident: 10.1016/j.biopha.2018.02.002_bib0105 article-title: Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method publication-title: Phytomedicine doi: 10.1016/j.phymed.2010.03.002 contributor: fullname: Elsas – volume: 4 start-page: 1339 year: 2013 ident: 10.1016/j.biopha.2018.02.002_bib0150 article-title: Caecal absorption of vitexin-2-O-xyloside and its aglycone apigenin, in the rat publication-title: Food Funct. doi: 10.1039/c3fo60047e contributor: fullname: Angelino – volume: 26 start-page: 451 year: 2016 ident: 10.1016/j.biopha.2018.02.002_bib0035 article-title: Chemical profiles of traditional preparations of four South American Passiflora species by chromatographic and capillary electrophoretic techniques publication-title: Braz. J. Pharmacogn. doi: 10.1016/j.bjp.2016.02.005 contributor: fullname: Costa |
| SSID | ssj0005638 |
| Score | 2.3721638 |
| Snippet | [Display omitted]
The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is... The aim of this study was to investigate the sedative activity of the aqueous leaf extract of Passiflora quadrangularis, a species that is widely cultivated... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 388 |
| SubjectTerms | Animals C-glycosylflavonoids Diazepam - pharmacology Dose-Response Relationship, Drug Flavonoids - isolation & purification Flavonoids - pharmacology GABA Modulators - pharmacology GABAergic Neurons - drug effects GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Hypnotics and Sedatives - isolation & purification Hypnotics and Sedatives - pharmacology Male Mice Passiflora Passiflora quadrangularis Passifloraceae Passion flower Plant Extracts - isolation & purification Plant Extracts - pharmacology Sedative Signal Transduction - drug effects Signal Transduction - physiology Vitexin-2’’-O-xyloside |
| Title | The sedative activity of flavonoids from Passiflora quadrangularis is mediated through the GABAergic pathway |
| URI | https://dx.doi.org/10.1016/j.biopha.2018.02.002 https://www.ncbi.nlm.nih.gov/pubmed/29454287 https://search.proquest.com/docview/2003048204 |
| Volume | 100 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1La9tAEF6cFEovpU1fbtqyhZJLoyBpV6-j27rOoSmmdqH0IlbaFVUwVrDshPTXd2Yfkk0IfUDByEbG1qL5NDuzO998hLxJZVAVAjJVyD4iDzvSeanwuSdjHotAlYVMkY18Oks-f0s_jPl4MHD8-_7cf7U0nANbI3P2L6zd_SmcgM9gcziC1eH4x3ZvlTT9vJG1cGmLLqqFuGyWTS1bwymZQthcV5CuC2RWyhUuXC5QkhA1zjWhBINRp-OD8elk9G6kVuAqsRvrjyuxuyOsefx6n17D6cL2xF7vti2YiJ-QTHellG0rwCWtlqrpNkMaG9BOlFZHRLE2cEPdAvcG22yvtfjT21m9QE1oJBzVfcWRaJEZI2wB4ScFucZKNtvLG0G6VRWj19wc7-YMbgp60NFsy0NCruUxZojNJ8p48CyCfNg3Urqdi_f9LSfNjJCgne-ZUWi8MZWYVY3zk6JusHEXjs10dw37qbMraJzhUHAkQYL7ykG6R-6E4PrQ836PvvRFR7HWVu8G7sicuuLw5pVuC5ZuS4Z0UDR_QO7bbIaODAwfkoFaHpC7ZxYHB-RoalBwfUznPdGvPaZHdNr3TL9-RBbwNXWwpQ62tKloD1uKsKU9bOkubCm8HGyphS28K9rBllrYPiZfP47n7089KwTilRBfrb2gzFTEeJFCrqIgohSJCLMijDO42cqvOE8gy6liFFyKq6CUcQphOYtiGcQwR5UJe0L2l81SPSM0ZWUWVoLzImScMSX8NCkFL2TlSwlz15B47o7nF6bfS-4KIc9zY6EcLZT7YQ4WGpLEmSW3MauJRXPA0W9--dpZMQeXXuonQzWbFpVhGUysoc-H5KkxbzeWMOMRrnI8_-frHpJ7_XP2guyvVxv1kuy1cvNKY_UXoMDSXw |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+sedative+activity+of+flavonoids+from+Passiflora+quadrangularis+is+mediated+through+the+GABAergic+pathway&rft.jtitle=Biomedicine+%26+pharmacotherapy&rft.au=Gazola%2C+Andressa+Corneo&rft.au=Costa%2C+Geison+Modesti&rft.au=Zucolotto%2C+Silvana+Maria&rft.au=Castellanos%2C+Leonardo&rft.date=2018-04-01&rft.pub=Elsevier+Masson+SAS&rft.issn=0753-3322&rft.eissn=1950-6007&rft.volume=100&rft.spage=388&rft.epage=393&rft_id=info:doi/10.1016%2Fj.biopha.2018.02.002&rft.externalDocID=S0753332217358018 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0753-3322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0753-3322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0753-3322&client=summon |