Dose-finding study of cilazapril (Inhibace) in patients with uncomplicated essential hypertension

• Published in: Clinical and experimental hypertension. Part A, Theory and practice Vol. 13; no. 8; p. 1415
• Main Authors: Mroczek, W J, Klein, J, Burris, J F
• Format: Journal Article
• Language: English
• Published: United States 1991
• Subjects: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Blood Pressure - drug effects; Cilazapril; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged; Pyridazines - administration & dosage; Pyridazines - adverse effects
• ISSN: 0730-0077
• DOI: 10.3109/10641969109048802

Cilazapril, an angiotensin converting enzyme (ACE) inhibitor with a long half-life, effectively reduced sitting diastolic blood pressure in patients with uncomplicated essential hypertension at dosages of 2.5, 5.0, and 10.0 mg/day, evaluated in a double-blind, placebo-controlled study. After a four-week placebo run-in period, 235 patients received either cilazapril or placebo for four weeks. At the end of the treatment period, significant decreases from baseline in sitting diastolic blood pressure were seen in all four groups (mean decreases of 3.3 mm Hg with placebo and 6.4, 9.2 and 8.3 mm Hg with 2.5, 5.0 and 10.0 mg cilazapril, respectively). The cilazapril groups had significantly greater blood pressure reductions than did the placebo group (p less than or equal to 0.02). The 5.0 mg cilazapril dose was significantly more effective than the 2.5 mg dose (p less than 0.03). The response rate was notably greater in the cilazapril treatment groups than in the placebo group (placebo, 27.5%; 2.5 mg cilazapril, 42.9%; 5.0 mg cilazapril 62.5%; 10.0 mg cilazapril, 50.0%). Cilazapril was well tolerated at all three dosages.