Potent humanin analog increases glucose‐stimulated insulin secretion through enhanced metabolism in the β cell

Humanin (HN) is a 24‐aa polypeptide that offers protection from Alzheimer's disease and myocardial infarction, increases insulin sensitivity, improves survival of β cells, and delays onset of diabetes. Here we examined the acute effects of HN on insulin secretion and potential mechanisms throug...

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Bibliographic Details
Published in:	The FASEB journal Vol. 27; no. 12; pp. 4890 - 4898
Main Authors:	Kuliawat, Regina, Klein, Laura, Gong, Zhenwei, Nicoletta‐Gentile, Marianna, Nemkal, Anjana, Cui, Lingguang, Bastie, Claire, Su, Kai, Huffman, Derek, Surana, Manju, Barzilai, Nir, Fleischer, Norman, Muzumdar, Radhika
Format:	Journal Article
Language:	English
Published:	Bethesda, MD, USA Federation of American Societies for Experimental Biology 01-12-2013
Subjects:	Animals Cells, Cultured diabetes Diabetes Mellitus, Type 2 - metabolism Glucose - metabolism hyperglycemic clamps Insulin - blood Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Intracellular Signaling Peptides and Proteins - pharmacology KATP Channels - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout pancreatic islets Rats Rats, Sprague-Dawley Receptors, Leptin - genetics Research Communications diabetes hyperglycemic clamps pancreatic islets
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