Role of genomic mechanisms on cAMP-dependent positive inotropism in isolated left atrium of rat

It is well known that β-adrenoceptor stimulation induces positive inotropism by cAMP-dependent phosphorylation of cardiac calcium channels. Furthermore, hypertrophy of different tissues including the heart have been related to the stimulation of these adrenoceptors via mechanisms coupled to activati...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 65; no. 5; pp. 565 - 572
Main Authors:	Rubín, JoséManuel, Hidalgo, Agustín, De Boto, M aJoséGarcía, Sánchez, Manuel
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 1999
Subjects:	Adrenergic beta-Agonists - pharmacology Animals Atrial Function Atrial Function, Left - genetics cAMP-dependent transcription Cyclic AMP - physiology Cycloheximide - pharmacology Dactinomycin - pharmacology Electric Stimulation forskolin Gene Expression Regulation - physiology Genome isoproterenol Isoproterenol - pharmacology Male Muscle Proteins - biosynthesis Muscle Proteins - genetics myocardial contractility Myocardial Contraction - genetics Protein Synthesis Inhibitors - pharmacology Rats Rats, Wistar Receptors, Adrenergic, beta - physiology Transcription, Genetic - drug effects forskolin cAMP-dependent transcription isoproterenol myocardial contractility
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