Association of SOCS5 gene polymorphism with allergic bronchial asthma

• Published in: Terapevtic̆eskii arhiv Vol. 91; no. 3; pp. 27 - 30
• Main Authors: Averyanov, A B, Chercashina, I I, Nikulina, S Yu, Maksimov, V N, Shestovitskiy, V A
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 30-03-2019
• Subjects: allele; allergy; bronchial asthma; gene; polymorphism; socs5; allergy; bronchial asthma; polymorphism; gene; allele; SOCS5
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/00403660.2019.03.000072

To study the association of mononucleotide polymorphism rs6737848 SOCS5 gene with the risk of development of allergic bronchial asthma.
Totally 59 patients studied (19 males, 40 females) with allergic bronchial asthma and 50 healthy people (29 males, 21 females) of controls. All patients underwent clinical and instrumental and laboratory investigations in KICH №20 (Krasnoyarsk city) and molecular-genetic investigation of DNA in the Russia-Italian laboratory "MAGI" (Krasnoyarsk city) and Institution of Internal and Preventive Medicine (Novosibirsk city). Statistics included standard programs: Statistica for Windows 7.0.
The results of the study showed statistical predominance of prevalent genotype СС of SOCS5 gene in allergic bronchial asthma patients, comparing to control group.
Homozygous genotype of СС gene of SOCS5 is a risk factor for allergic bronchial asthma.